Li Yi-Zhong, Zhuang Hua-Feng, Cai Si-Qing, Lin Chang-Kun, Wang Pei-Wen, Yan Li-Sheng, Lin Jin-Kuang, Yu Hai-Ming
Department of Orthopaedics, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Department of Radiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Orthop Surg. 2018 Feb;10(1):17-22. doi: 10.1111/os.12360. Epub 2018 Feb 12.
To investigate the effect of grip strength on bone mineral density (BMD) in postmenopausal women. Low BMD is related to risk of fracture and falling is the strongest factor for fragility fractures. Handgrip strength is a reliable indicator of muscle strength and muscle strength is associated with falling.
For the present study 120 women were divided into two groups: those ≤65 years and those >65 years. Serum 25 hydroxyvitamin D (25OHD), BMD, and handgrip strength were measured to observe the effect of age on 25OHD, grip strength, and BMD, as well as the effect of 25OHD on grip strength and BMD. The correlation between grip strength and BMD was investigated.
In the 120 patients, 25OHD was 24.31 ± 8.29 ng/mL. There were 37 cases with 25OHD <20 ng/mL and 83 cases with 25 OHD ≥20 ng/mL. The patients with 25OHD <20 ng/mL had significantly lower femoral neck BMD, most of them with a T score ≤-2.5 (P < 0.05). BMD measurement showed 66 patients with femoral neck T ≤-2.5, 30 cases with total hip T ≤-2.5 and 90 cases with lumbar BMD T ≤-2.5. The maximum grip strength in the group is 22.28 ± 6.17 kg. There were 38 cases with the maximum grip strength <20 kg and 82 cases with the maximum grip strength ≥20 kg. Patients >65 years had lower 25OHD, lower maximum grip strength, and lower BMD. The osteoporosis risk in postmenopausal women with a maximum grip strength <20 kg and who were >65 years was significantly elevated.
Handgrip strength and 25OHD decrease with aging in postmenopausal women. The patients with lower 25OHD level had significantly lower BMD of femoral neck. The patients with lower handgrip strength had significantly lower BMD of lumbar spine, femoral neck, and total hip. Grip strength measurement is the simplest muscle strength measurement method. Our study confirmed that low grip strength was correlated with low BMD and was a strong risk factor for osteoporosis in postmenopausal women.
探讨握力对绝经后女性骨密度（BMD）的影响。低骨密度与骨折风险相关，而跌倒则是脆性骨折的最强危险因素。握力是肌肉力量的可靠指标，且肌肉力量与跌倒相关。
在本研究中，120名女性被分为两组：年龄≤65岁组和年龄>65岁组。测量血清25羟维生素D（25OHD）、骨密度和握力，以观察年龄对25OHD、握力和骨密度的影响，以及25OHD对握力和骨密度的影响。研究握力与骨密度之间的相关性。
120例患者中，25OHD为24.31±8.29 ng/mL。25OHD<20 ng/mL者有37例，25OHD≥20 ng/mL者有83例。25OHD<20 ng/mL的患者股骨颈骨密度显著较低，其中大多数T值≤-2.5（P<0.05）。骨密度测量显示，66例患者股骨颈T值≤-2.5，30例患者全髋T值≤-2.5，90例患者腰椎骨密度T值≤-2.5。该组的最大握力为22.28±6.17 kg。最大握力<20 kg者有38例，最大握力≥20 kg者有82例。年龄>65岁的患者25OHD较低，最大握力较低，骨密度也较低。最大握力<20 kg且年龄>65岁的绝经后女性骨质疏松风险显著升高。
绝经后女性的握力和25OHD随年龄增长而下降。25OHD水平较低的患者股骨颈骨密度显著较低。握力较低的患者腰椎、股骨颈和全髋的骨密度显著较低。握力测量是最简单的肌肉力量测量方法。我们的研究证实，低握力与低骨密度相关，是绝经后女性骨质疏松的一个强危险因素。
