Department of Obstetrics and Gynecology, University Hospital of Bern, Bern, Switzerland.
Department of Obstetrics and Gynecology, Hospital Thun, Thun, Switzerland.
Obes Rev. 2023 Oct;24(10):e13605. doi: 10.1111/obr.13605. Epub 2023 Aug 6.
The fear of weight gain is one of the main reasons for women not to initiate or to early discontinue hormonal contraception or menopausal hormone therapy. Resting energy expenditure is by far the largest component and the most important determinant of total energy expenditure. Given that low resting energy expenditure is a confirmed predictive factor for weight gain and consecutively for the development of obesity, research into the influence of sex steroids on resting energy expenditure is a particularly exciting area. The objective of this systematic review was to evaluate the effects of medication with natural and synthetic estrogens on resting energy expenditure in healthy normal weight and overweight women. Through complex systematic literature searches, a total of 10 studies were identified that investigated the effects of medication with estrogens on resting energy expenditure. Our results demonstrate that estrogen administration increases resting energy expenditure by up to +208 kcal per day in the context of contraception and by up to +222 kcal per day in the context of menopausal hormone therapy, suggesting a preventive effect of circulating estrogen levels and estrogen administration on weight gain and obesity development.
对体重增加的恐惧是女性不开始或过早停止激素避孕或绝经激素治疗的主要原因之一。静息能量消耗是迄今为止最大的组成部分，也是总能量消耗的最重要决定因素。鉴于低静息能量消耗是体重增加和随之而来的肥胖发展的一个已确认的预测因素，因此研究性激素对静息能量消耗的影响是一个特别令人兴奋的领域。本系统评价的目的是评估天然和合成雌激素药物对健康正常体重和超重女性静息能量消耗的影响。通过复杂的系统文献检索，共确定了 10 项研究，这些研究调查了雌激素药物对静息能量消耗的影响。我们的研究结果表明，雌激素给药在避孕的情况下将静息能量消耗增加了高达+208 kcal/天，在绝经激素治疗的情况下增加了高达+222 kcal/天，这表明循环雌激素水平和雌激素给药对体重增加和肥胖发展具有预防作用。
