Rattley Catherine A, Ansdell Paul, Armstrong Matthew, Felton Malika, Dewhurst Susan, Yendole Karen, Neal Rebecca A
Division of Surgery and Interventional Science, Institute of Sport, Exercise and Health, University College London, London, UK.
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-Upon-Tyne, UK.
Eur J Appl Physiol. 2025 Sep 19. doi: 10.1007/s00421-025-05981-1.
This study aimed to investigate the differences in metabolism and ventilation between women before, during, and after menopause during rest and to varying steady-state exercise intensities.
74 female participants (18-60 years; premenopausal [PRE], perimenopausal [PERI], and postmenopausal [POST]) completed four laboratory visits; one maximal exercise test, resting data collection, and body composition assessment followed by three steady-state submaximal exercise tests at 40% (low), 60% (moderate), and 80% (high) V̇O in a randomised order with subgroup analysis for hormonal contraceptive or hormone therapy use.
There was an effect of menopause stage on exercise energy expenditure but no interaction effect with intensity. There were no differences substrate utilisation, or ventilation across any of the exercise intensities. Subgroup analysis revealed that HT and HC use did not impact EE, substrate oxidation, or ventilation.
Menopause stage is influential upon exercise energy expenditure but more research in perimenopause is required to confirm the effect, future studies should explore the broader implications of the menopausal transition on exercise physiology.
本研究旨在调查绝经前、绝经期间和绝经后女性在静息状态以及不同稳态运动强度下的代谢和通气差异。
74名女性参与者（年龄18 - 60岁；绝经前[PRE]、围绝经期[PERI]和绝经后[POST]）完成了四次实验室访视；一次最大运动测试、静息数据收集和身体成分评估，随后以随机顺序进行三次稳态次最大运动测试，运动强度分别为40%（低）、60%（中）和80%（高）最大摄氧量，并对激素避孕或激素治疗的使用情况进行亚组分析。
绝经阶段对运动能量消耗有影响，但与运动强度无交互作用。在任何运动强度下，底物利用或通气均无差异。亚组分析显示，使用激素治疗（HT）和激素避孕（HC）对能量消耗、底物氧化或通气无影响。
绝经阶段对运动能量消耗有影响，但需要更多关于围绝经期的研究来证实这一效应，未来的研究应探讨绝经过渡对运动生理学的更广泛影响。
