Mandal Tirtha, Katta Narenderreddy, Paps Hendrik, Reiser Oliver
Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
ACS Org Inorg Au. 2023 May 22;3(4):171-176. doi: 10.1021/acsorginorgau.3c00011. eCollection 2023 Aug 2.
A sequential photocatalytic strategy is developed via the merger of Cu(II)/Cu(I)-catalytic cycles for the oxoallylation of vinyl arenes via α-haloketones. The initial Cu(II)-photocatalyzed oxohalogenation exploits ligand-to-metal charge transfer (LMCT) to generate halide radicals from acyl halides utilizing air as a terminal oxidant and can be employed for the late-stage modification of pharmaceuticals and agrochemicals. α-Bromoketones obtained this way can be subsequently subjected to a one-pot Cu(I)-photocatalyzed allylation. This sequential photocatalysis proceeds in a highly regio- and chemoselective fashion and is inconsequential to the electronic nature of styrenes.
通过铜（II）/铜（I）催化循环的合并，开发了一种用于通过α-卤代酮对乙烯基芳烃进行氧代烯丙基化的顺序光催化策略。最初的铜（II）光催化氧卤化利用配体到金属的电荷转移（LMCT），以空气作为终端氧化剂从酰卤中产生卤化物自由基，并且可用于药物和农用化学品的后期修饰。以这种方式获得的α-溴代酮随后可以进行一锅法铜（I）光催化烯丙基化。这种顺序光催化以高度区域选择性和化学选择性的方式进行，并且与苯乙烯的电子性质无关。
