铜催化的自由基羰氧官能团化：苯乙烯的烷基化和烷氧基化反应。
Copper-catalyzed radical carbooxygenation: alkylation and alkoxylation of styrenes.
机构信息
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, School of Pharmaceutical Sciences, Wuhan, 430071 (P. R. China); College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P. R. China), Fax: (+86) 27-68754672.
出版信息
Chem Asian J. 2015 Jan;10(1):96-9. doi: 10.1002/asia.201403097. Epub 2014 Oct 29.
A simple copper-catalyzed direct radical carbooxygenation of styrenes is developed utilizing alkyl bromides as radical resources. This catalytic radical difunctionalization accomplishes both alkylation and alkoxylation of styrenes in one pot. A broad range of styrenes and alcohols are well tolerated in this transformation. The EPR experiment shows that alkyl halides could oxidize Cu(I) to Cu(II) in this transformation.
发展了一种简单的铜催化的苯乙烯直接自由基羰氧官能团化反应，利用溴代烷烃作为自由基源。这种催化的自由基双官能团化反应可以一锅法实现苯乙烯的烷基化和烷氧基化。在这个转化中，广泛的苯乙烯和醇都可以很好地耐受。EPR 实验表明，在这个转化中，卤代烷烃可以将 Cu(I)氧化为 Cu(II)。
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