Fijałkowska Marta, Bonczar Michał, Jastrzębski Ignacy, Ostrowski Patryk, Antoszewski Bogusław, Koziej Mateusz
Department of Plastic, Reconstructive, and Aesthetic Surgery, Second Chair of Surgery, Medical University of Lodz, Lodz, Poland.
Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
Postepy Dermatol Alergol. 2023 Jun;40(3):384-389. doi: 10.5114/ada.2023.124747. Epub 2023 Feb 1.
Basal cell carcinoma (BCC) is the most common skin cancer in humans, occurring in more than 50% of Caucasians during their lifetime, with a frequency rate that is continually increasing.
We present a systematic review summarizing the role of transforming growth factor β (TGF-β), cathelicidin, and human β-defensins (HBDs) in the pathogenesis of BCC. The major online databases including PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to extract studies regarding the levels of TGF-β, HBD, and cathelicidin in BCC.
A total of 14 studies met the inclusion criteria and were included in this systematic review. There were 6 studies that included initially established levels of TGF-β in BCCs. A total of 87 BCCs were analysed, and a common result was that the TGF-β levels increase in the BCCs compared to the control groups. Analogously, 2 studies contained numerical data on HBD levels but with a different in methodology. The level of cathelicidin was established in 108 BCCs and was significantly higher in the BCC group than in the control group.
The presented review shows evidence that proteins like TGF-β, HBD, and cathelicidin play a role in developing BCC. Protein levels or their expression are elevated in patients with BCC. Furthermore, a critical review of the literature was presented and discussed, highlighting its shortcomings.
基底细胞癌（BCC）是人类最常见的皮肤癌，超过50%的白种人在其一生中会患上这种疾病，且发病率持续上升。
我们进行了一项系统综述，总结转化生长因子β（TGF-β）、杀菌肽和人β-防御素（HBDs）在基底细胞癌发病机制中的作用。检索了包括PubMed、Scopus、Embase、科学网、Cochrane图书馆和谷歌学术在内的主要在线数据库，以提取有关基底细胞癌中TGF-β、HBD和杀菌肽水平的研究。
共有14项研究符合纳入标准并被纳入本系统综述。有6项研究纳入了基底细胞癌中最初确定的TGF-β水平。总共分析了87例基底细胞癌，一个常见的结果是与对照组相比，基底细胞癌中的TGF-β水平升高。类似地，有2项研究包含了关于HBD水平的数值数据，但方法不同。在108例基底细胞癌中确定了杀菌肽水平，基底细胞癌组的杀菌肽水平显著高于对照组。
本综述表明，TGF-β、HBD和杀菌肽等蛋白质在基底细胞癌的发生中起作用。基底细胞癌患者的蛋白质水平或其表达升高。此外，还对文献进行了批判性综述和讨论，突出了其不足之处。
