Bednarski Igor Aleksander, Ciążyńska Magdalena, Wódz Karolina, Dróżdż Izabela, Skibińska Małgorzata, Narbutt Joanna, Lesiak Aleksandra
Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, 91-347 Lodz, Poland.
Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, 93-513 Lodz, Poland.
Life (Basel). 2021 Jul 12;11(7):680. doi: 10.3390/life11070680.
Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most frequently diagnosed cancers in humans, however, their exact pathogenesis is not fully understood. In recent years, it has been hypothesized that the recently discovered Hippo pathway could play a detrimental role in cutaneous carcinogenesis, but no direct connections have been made. The Hippo pathway and its effector, YAP, are responsible for tissue growth by accelerating cell proliferation, however, YAP upregulation and overexpression have also been reported in numerous types of tumors. There is also evidence that disrupted YAP/Hippo signaling is responsible for cancer growth, invasion, and metastasis. In this short review, we will explore whether the Hippo pathway is an important regulator of skin carcinogenesis and if it could be a promising target for future therapies.
非黑色素瘤皮肤癌（NMSCs），包括基底细胞癌（BCC）和皮肤鳞状细胞癌（cSCC），是人类中最常被诊断出的癌症，然而，其确切发病机制尚未完全明确。近年来，有人提出最近发现的Hippo信号通路可能在皮肤癌发生过程中起有害作用，但尚未建立直接联系。Hippo信号通路及其效应分子YAP通过加速细胞增殖来调控组织生长，然而，在多种类型的肿瘤中也有YAP上调和过表达的报道。也有证据表明，YAP/Hippo信号通路紊乱与癌症生长、侵袭和转移有关。在这篇简短的综述中，我们将探讨Hippo信号通路是否是皮肤癌发生的重要调节因子，以及它是否可能成为未来治疗的一个有前景的靶点。
