Selcuk University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology 42250 Konya, Turkey.
Selcuk University, Faculty of Medicine, Department of Medical Biochemistry 42250 Konya, Turkey.
Afr Health Sci. 2023 Mar;23(1):37-43. doi: 10.4314/ahs.v23i1.5.
The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions.
This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19.
This study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1.
The MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups.
Diagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predicting lung involvement in COVID-19 and directing clinical outcomes.
COVID-19 的进展具有不同的临床表现，这引发了许多免疫学问题。
本研究旨在探讨 COVID-19 患者中 MMP-9 和 TIMP-1 水平，以及 MMP-9/TIMP-1 比值是否与 COVID-19 中的肺受累有关。
本研究纳入了 192 名患者和 45 名健康对照。采用 ELISA 法检测 MMP-9 和 TIMP-1。
患者的 MMP-9 和 TIMP-1 水平高于对照组。在胸部 CT 扫描中发现有肺受累的患者中检测到 MMP-9 和 TIMP-1 ，而在胸部 CT 扫描中没有肺受累的患者中未检测到。对肺受累程度进行比较，两组间无差异。在胸部 CT 扫描中有肺受累的组中 MMP-9/TIMP-1 比值为 5.8，在胸部 CT 扫描中无肺受累的组中 MMP-9/TIMP-1 比值为 6.1。两组间无差异。对肺受累程度进行比较，两组间 MMP-9/TIMP-1 比值差异有统计学意义。
针对 MMP-9 活性或中性粒细胞活化的诊断和治疗方法可能对预测 COVID-19 中的肺受累和指导临床结局具有重要意义。
