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铜死亡相关基因表达与胶质母细胞瘤中的免疫浸润及CD47/CD24表达相关，基于这些基因的风险评分可预测患者的生存和预后。

Cuproptosis-related gene expression is associated with immune infiltration and CD47/CD24 expression in glioblastoma, and a risk score based on these genes can predict the survival and prognosis of patients.

作者信息

Li Erliang, Qiao Huanhuan, Sun Jin, Ma Qiong, Lin Li, He Yixiang, Li Shuang, Mao Xinggang, Zhang Xiaoping, Liao Bo

机构信息

Department of Orthopaedics, The Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, China.

Department of Orthopaedics, The First Affiliated Hospital of Lanzhou University, Gansu, China.

出版信息

Front Oncol. 2023 Jul 20;13:1011476. doi: 10.3389/fonc.2023.1011476. eCollection 2023.

DOI:10.3389/fonc.2023.1011476
PMID:37546426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10399623/
Abstract

INTRODUCTION

Glioblastoma (GBM) is the most invasive type of glioma, is insensitive to radiotherapy and chemotherapy, and has high proliferation and invasive ability, with a 5-year survival rate of <5%. Cuproptosis-related genes (CRGs) have been successfully used to predict the prognosis of many types of tumors. However, the relationship between cuproptosis and GBM remains unclear.

METHODS

Here, we sought to identify CRGs in GBM and elucidate their role in the tumor immune microenvironment and prognosis. To that aim, changes in CRGs in The Cancer Genome Atlas (TCGA) transcriptional and Gene Expression Omnibus (GEO) datasets (GEO4290 and GEO15824) were characterized, and the expression patterns of these genes were analyzed.

RESULTS

A risk score based on CRG expression characteristics could predict the survival and prognosis of patients with GBM and was significantly associated with immune infiltration levels and the expression of CD47 and CD24, which are immune checkpoints of the "don't eat me "signal. Furthermore, we found that the CDKN2A gene may predict GBM sensitivity and resistance to drugs.

DISCUSSION

Our findings suggest that CRGs play a crucial role in GBM outcomes and provide new insights into CRG-related target drugs/molecules for cancer prevention and treatment.

摘要

引言

胶质母细胞瘤（GBM）是最具侵袭性的胶质瘤类型，对放疗和化疗不敏感，具有高增殖和侵袭能力，5年生存率<5%。铜死亡相关基因（CRGs）已成功用于预测多种肿瘤的预后。然而，铜死亡与GBM之间的关系仍不清楚。

方法

在此，我们试图在GBM中鉴定CRGs，并阐明它们在肿瘤免疫微环境和预后中的作用。为此，我们对癌症基因组图谱（TCGA）转录组和基因表达综合数据库（GEO）数据集（GEO4290和GEO15824）中CRGs的变化进行了表征，并分析了这些基因的表达模式。

结果

基于CRG表达特征的风险评分可以预测GBM患者的生存和预后，并且与免疫浸润水平以及“别吃我”信号的免疫检查点CD47和CD24的表达显著相关。此外，我们发现CDKN2A基因可能预测GBM对药物的敏感性和耐药性。

讨论

我们的研究结果表明，CRGs在GBM的预后中起着关键作用，并为癌症预防和治疗中与CRG相关的靶标药物/分子提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8c3/10399623/373181a4c016/fonc-13-1011476-g007.jpg
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