National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Clin Transl Oncol. 2022 Jan;24(1):1-12. doi: 10.1007/s12094-021-02669-8. Epub 2021 Jun 23.
Compared with the traditional forms of cell death-apoptosis, necrosis and autophagy, ferroptosis is a novel form of iron-dependent programmed cell death forms which is different from the above traditional forms of cell death. Brent R Stockwell, a Professor of Columbia University, firstly proposed that this from of cell death was named ferroptosis in 2012. The main characteristics of ferroptosis is increasing iron loading and driving a lot of lipid peroxide generated and ultimately lead to cell death. In this paper, the mechanism of ferroptosis, relationship between ferroptosis and common diseases and immune state of body are reviewed, and the inhibitors and inducers related to ferroptosis that have been found are summarized to provide medicine exploration targeted of ferroptosis and reference for the research in the future.
与传统的细胞死亡形式——凋亡、坏死和自噬相比，铁死亡是一种新型的铁依赖性程序性细胞死亡形式，与上述传统的细胞死亡形式不同。2012 年，哥伦比亚大学教授布伦特·R·斯托克韦尔首次提出将这种细胞死亡形式命名为铁死亡。铁死亡的主要特征是增加铁的负载并驱动大量脂质过氧化物的产生，最终导致细胞死亡。本文综述了铁死亡的机制、铁死亡与常见疾病和机体免疫状态的关系，总结了已发现的与铁死亡相关的抑制剂和诱导剂，为铁死亡的药物探索提供靶点，为未来的研究提供参考。
