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深部脑刺激治疗运动障碍的并发症:文献回顾与个人经验。

Complications of Deep Brain Stimulation for Movement Disorders: Literature Review and Personal Experience.

机构信息

International Research Institute of Postgraduate Education and Shashkin Clinic, Almaty, Kazakhstan.

出版信息

Acta Neurochir Suppl. 2023;130:121-126. doi: 10.1007/978-3-030-12887-6_15.

DOI:10.1007/978-3-030-12887-6_15
PMID:37548731
Abstract

The contemporary technique of deep brain stimulation (DBS) is very effective for management of movement disorders-including Parkinson's disease, generalized dystonia, and tremors-and has also been successfully applied for novel indications (e.g., intractable epilepsy and chronic pain). As a result, growing numbers of DBS procedures have been performed worldwide; correspondingly, the incidence of associated morbidity has also increased. All complications of DBS can be divided into those associated with (1) the surgical procedure, (2) the device itself, and (3) the applied electrical stimulation. On the basis of an analysis of the available literature and the personal experience of the author, it may be concluded that implantation of a DBS device is a relatively safe procedure accompanied by very low risks of major morbidity or a permanent neurological deficit. Nevertheless, awareness of the possible complications and application of appropriate preventive measures for their avoidance are very important for providing safe and effective treatment.

摘要

目前,深部脑刺激(DBS)技术在运动障碍的治疗方面非常有效,包括帕金森病、全身性肌张力障碍和震颤,也已成功应用于新的适应症(如难治性癫痫和慢性疼痛)。因此,全球进行的 DBS 手术数量不断增加,相应地,相关发病率也有所增加。DBS 的所有并发症都可以分为与(1)手术过程、(2)设备本身和(3)应用的电刺激相关的并发症。根据对现有文献的分析和作者的个人经验,我们可以得出结论,DBS 设备的植入是一种相对安全的手术,其主要发病率或永久性神经功能缺损的风险非常低。然而,了解可能出现的并发症并采取适当的预防措施来避免这些并发症是非常重要的,这对于提供安全有效的治疗非常重要。

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本文引用的文献

1
Hardware-related complications of deep brain stimulation: a ten year experience.脑深部电刺激的硬件相关并发症:十年经验
Acta Neurochir (Wien). 2005 Oct;147(10):1061-4; discussion 1064. doi: 10.1007/s00701-005-0576-5. Epub 2005 Jul 25.
2
Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.帕金森病双侧脑深部电刺激:一项为期4年随访的多中心研究
Brain. 2005 Oct;128(Pt 10):2240-9. doi: 10.1093/brain/awh571. Epub 2005 Jun 23.
3
Incidence of hemorrhage associated with electrophysiological studies performed using macroelectrodes and microelectrodes in functional neurosurgery.
在功能神经外科中使用宏观电极和微观电极进行电生理研究时出血的发生率。
J Neurosurg. 2005 May;102(5):888-96. doi: 10.3171/jns.2005.102.5.0888.
4
Bilateral subthalamic nucleus stimulation for Parkinson's disease: a systematic review of the clinical literature.双侧丘脑底核刺激治疗帕金森病:临床文献的系统评价
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Effect of subthalamic stimulation on mood state in Parkinson's disease: evaluation of previous facts and problems.丘脑底核刺激对帕金森病情绪状态的影响:既往事实与问题评估
Neurosurg Rev. 2005 Jul;28(3):179-86; discussion 187. doi: 10.1007/s10143-005-0387-4. Epub 2005 Apr 13.
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Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders.用于运动障碍的微电极引导深部脑刺激器植入术中出血的危险因素。
Neurosurgery. 2005 Apr;56(4):722-32; discussion 722-32. doi: 10.1227/01.neu.0000156473.57196.7e.
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Suicide after successful deep brain stimulation for movement disorders.
Neurology. 2004 Dec 14;63(11):2170-2. doi: 10.1212/01.wnl.0000145603.48221.b5.
8
Unilateral battery depletion in Parkinson's disease patients treated with bilateral subthalamic nucleus deep brain stimulation may require urgent surgical replacement.接受双侧丘脑底核深部脑刺激治疗的帕金森病患者出现单侧电池耗尽可能需要紧急手术更换。
Stereotact Funct Neurosurg. 2004;82(4):153-5. doi: 10.1159/000081348. Epub 2004 Oct 5.
9
Surgical and hardware complications of subthalamic stimulation: a series of 160 procedures.丘脑底核刺激的手术及硬件并发症:160例手术系列报道
Neurology. 2004 Aug 24;63(4):612-6. doi: 10.1212/01.wnl.0000134650.91974.1a.
10
Psychiatric complications of deep brain stimulation for Parkinson's disease.帕金森病深部脑刺激的精神并发症
J Clin Psychiatry. 2004 Jun;65(6):845-9. doi: 10.4088/jcp.v65n0617.