Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 600 077, Tamil Nadu, India.
Cell Tissue Res. 2023 Nov;394(2):245-255. doi: 10.1007/s00441-023-03815-0. Epub 2023 Aug 7.
Recent years have seen the emergence of tissue engineering strategies as a means to overcome some of the limits of conventional medical treatment. A biomaterial with tailored physio-chemical characteristics is used in this sophisticated method to transport stem cells and growth factors/bioactive substances, or to attract local endogenous cells, enabling new tissue formation. Biomaterials might serve as a biomimetic structure inspired by the natural milieu, assisting the cells in establishing their natural relationships. Such a method would benefit from having ready access to an abundant reservoir of stem cells with strong tissue regeneration capacity, in addition to using biological compatible material to promote new tissue creation. Teeth may have a plethora of self-renewing, multipotent mesenchymal stem cell (MSC) populations. Recent advancements and promising directions for cell transplantation and homing techniques using dental MSCs for tissue regeneration are discussed in this review paper. Overall, this research paints a picture of the present landscape of new approaches to using tooth-derived MSCs in conjunction with biomaterials and bioactive substances for tissue regeneration.
近年来，组织工程策略作为一种克服传统医学治疗局限性的手段而出现。在这种复杂的方法中，使用具有定制的物理化学特性的生物材料来输送干细胞和生长因子/生物活性物质，或吸引局部内源性细胞，从而促进新组织的形成。生物材料可以作为受自然环境启发的仿生结构，帮助细胞建立其自然关系。这种方法将受益于能够大量获得具有强大组织再生能力的干细胞，并且还可以使用生物相容性材料来促进新组织的生成。牙齿可能具有大量自我更新的、多能间充质干细胞（MSC）群体。本文综述了近年来利用牙源性 MSC 进行细胞移植和归巢技术以促进组织再生的最新进展和有前景的方向。总的来说，这项研究描绘了目前利用牙源性 MSC 与生物材料和生物活性物质结合进行组织再生的新方法的现状。
