Li Anni, Li Xiangyi, Ma Fang, Gao Hui, Li Hongji
Key Laboratory of Green and Precise Synthetic Chemistry, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei 235000, Anhui, P. R. China.
Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
Org Lett. 2023 Aug 18;25(32):5978-5983. doi: 10.1021/acs.orglett.3c02099. Epub 2023 Aug 7.
An electrochemical oxidation-induced cyclization of -alkyl-substituted azobenzenes has been developed. The direct electrochemical benzylic C-H functionalization with respect to azobenzenes could proceed in the absence of any catalyst or external chemical oxidant to afford a number of 2-indazole derivatives in moderate to good yields. This protocol enables the reuse of the byproduct to the same 2-indazoles, thus significantly reducing pollution discharge in synthetic chemistry.
已开发出一种电化学氧化诱导的-烷基取代偶氮苯的环化反应。关于偶氮苯的直接电化学苄基C-H官能化反应可以在没有任何催化剂或外部化学氧化剂的情况下进行，以中等至良好的产率得到多种2-吲唑衍生物。该方法能够将副产物再利用生成相同的2-吲唑，从而显著减少合成化学中的污染排放。
