The First Clinical College, Guangdong Medical University, Zhanjiang, Guangdong, China.
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Aging Dis. 2024 Apr 1;15(2):714-738. doi: 10.14336/AD.2023.0717.
Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be closely associated with the development of many diseases. Mitochondria are vital components of eukaryotic cells, serving important functions in energy production, cellular metabolism, and apoptosis regulation. Presently, the precise relationship between mitochondria and ferroptosis remains unclear. In this study, we aim to systematically elucidate the mechanisms via which mitochondria regulate ferroptosis from multiple perspectives to provide novel insights into mitochondrial functions in ferroptosis. Additionally, we present a comprehensive overview of how mitochondria contribute to ferroptosis in different conditions, including cancer, cardiovascular disease, inflammatory disease, mitochondrial DNA depletion syndrome, and novel coronavirus pneumonia. Gaining a comprehensive understanding of the involvement of mitochondria in ferroptosis could lead to more effective approaches for both basic cell biology studies and medical treatments.
铁死亡是一种涉及铁和脂质过氧化的细胞死亡方式，与许多疾病的发生密切相关。线粒体是真核细胞的重要组成部分，在能量产生、细胞代谢和细胞凋亡调节中发挥着重要作用。目前，线粒体与铁死亡之间的确切关系尚不清楚。在这项研究中，我们旨在从多个角度系统阐明线粒体调节铁死亡的机制，为线粒体在铁死亡中的功能提供新的见解。此外，我们还全面介绍了线粒体在不同条件下（包括癌症、心血管疾病、炎症性疾病、线粒体 DNA 耗竭综合征和新型冠状病毒肺炎）如何促进铁死亡。全面了解线粒体在铁死亡中的作用可能会为基础细胞生物学研究和医学治疗提供更有效的方法。
