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Sfrp5/Wnt 通路：动脉粥样硬化性心血管疾病中的保护性调节系统。

Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease.

机构信息

1Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Department of Cardiology, 12th ward, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing, China.

2Department of Geriatric Medicine and Gerontology, Hainan General Hospital, Hainan, China.

出版信息

J Interferon Cytokine Res. 2019 Aug;39(8):472-482. doi: 10.1089/jir.2018.0154. Epub 2019 Jun 13.

DOI:10.1089/jir.2018.0154
PMID:31199714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6660834/
Abstract

Adipose tissue stores energy and is the largest endocrine organ in the body, producing several adipokines. However, among these adipokines, few play a role in the positive metabolism that promotes good health. Secreted frizzled-related protein (Sfrp)-5, an antagonist that directly binds to Wnt, has attracted interest due to its favorable effects on atherosclerotic cardiovascular disease (ASCVD). This review focuses on Sfrp5 biology and the roles of the Sfrp5/Wnt system in ASCVD.

摘要

脂肪组织储存能量，是人体最大的内分泌器官，能产生多种脂肪因子。然而，在这些脂肪因子中，只有少数能够发挥促进健康的积极代谢作用。卷曲相关蛋白 5（Secreted frizzled-related protein-5，Sfrp5）是一种能与 Wnt 直接结合的拮抗剂，因其对动脉粥样硬化性心血管疾病（atherosclerotic cardiovascular disease，ASCVD）的有益作用而备受关注。本综述重点介绍了 Sfrp5 的生物学特性以及 Sfrp5/Wnt 系统在 ASCVD 中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84d/6660834/75c04196efa3/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84d/6660834/75c04196efa3/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f84d/6660834/75c04196efa3/fig-1.jpg

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