Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
Department of Thyroid Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Biosci Rep. 2018 Jul 2;38(4). doi: 10.1042/BSR20180011. Print 2018 Aug 31.
Various reports have suggested that secreted frizzled-related protein (SFRP) 5 (SFRP5) plays a regulatory role in the processes of cellular proliferation and differentiation, by means of inactivating the Wnt/β-catenin signaling pathway. Recently, SFRP5 has been identified as an anti-inflammatory adipokine, which may be induced during preadipocyte proliferation, differentiation, and maturation. This review aims to identify the recent progress in the research and development of SFRP5 that can play a role in influencing lipid metabolism, inflammation, and type 2 diabetes mellitus (T2DM). Recent evidence has indicated that SFRP5 is capable of stimulating adipocyte differentiation via inhibition of the Wnt/β-catenin signaling pathway. In addition, SFRP5 binding with wingless-type murine mammary tumor virus integration site family, member 5A (Wnt5a), inhibits the activation of c-Jun N-terminal kinase (JNK) downstream of the Wnt signaling pathway. An antagonistic relationship has been found between the reductions in inflammatory cytokine production and serine phosphorylation of insulin receptor substrate-1 (IRS-1) in regard to inhibition of insulin signaling network. By this mechanism, SFRP5 exerts its influence on metabolic function. Based on our review of the current available literature, we support the notion that SFRP5 can be used as a therapeutic target in the treatment of T2DM.
各种报告表明，分泌卷曲相关蛋白 5（SFRP5）通过使 Wnt/β-连环蛋白信号通路失活，在细胞增殖和分化过程中发挥调节作用。最近，SFRP5 被鉴定为一种抗炎脂肪因子，它可能在脂肪细胞增殖、分化和成熟过程中被诱导产生。本综述旨在确定 SFRP5 在影响脂质代谢、炎症和 2 型糖尿病（T2DM）方面的研究和开发的最新进展。最近的证据表明，SFRP5 可以通过抑制 Wnt/β-连环蛋白信号通路来刺激脂肪细胞分化。此外，SFRP5 与 Wnt 信号通路下游的 c-Jun N 端激酶（JNK）的激活结合，抑制 wingless-type murine mammary tumor virus integration site family, member 5A（Wnt5a）。在抑制胰岛素信号网络方面，已经发现炎症细胞因子产生减少和胰岛素受体底物-1（IRS-1）丝氨酸磷酸化之间存在拮抗关系。通过这种机制，SFRP5 对代谢功能产生影响。基于我们对现有文献的综述，我们支持 SFRP5 可作为治疗 T2DM 的治疗靶点的观点。
