Cerilli J, Fesperman D P
Transplantation. 1979 Apr;27(4):279-82. doi: 10.1097/00007890-197904000-00015.
Seventy-four recipients of related donor renal allografts were tested for the presence of cellular immunity to specific donor lymphocyte antigens using the direct migration inhibition factor (MIF) assay. Responses on the assay fell into one of the following three statistically distinct groups: (1) greater than 20% inhibition of macrophage migration, (2) nonresponsiveness, +/- 10% of control migration, and (3) greater than 12% stimulation of macrophage migration. Migration stimulation was shown to be reproducible and to correlate well with a very benign post-transplant clinical course. The production of migration stimulatory factor appears to be an immunological response analagous to the production of migration inhibition factor.
使用直接迁移抑制因子（MIF）测定法，对74名接受亲属供体肾移植的受者进行了针对特定供体淋巴细胞抗原的细胞免疫检测。该测定法的反应分为以下三个统计学上不同的组之一：（1）巨噬细胞迁移抑制率大于20%，（2）无反应，即与对照迁移相比变化在±10%以内，（3）巨噬细胞迁移刺激率大于12%。已证明迁移刺激是可重复的，并且与移植后非常良性的临床病程密切相关。迁移刺激因子的产生似乎是一种类似于迁移抑制因子产生的免疫反应。
