Friemel H, Brock J, Jenssen H L, Köhler H, Solga U, May G, Philipp H
Z Exp Chir. 1975;8(6):350-5.
Decisive for controlling renal transplantation is the knowledge of the immunological reactions. The cellular immuno-mechanisms, released via sensibilization by donor HL-A antigens, are specially important for acute rejection. To predict a crisis of rejection and to initiate increased immuno-suppressive measures it is important to know the degree of cellular immunologic response. The sensibilization was demonstrated in the experiments by means of the MEM test, using graft antigens isolated from spleen or kidney of the donor. In all patients an increasing sensibilization against donor antigen could be proved. The velocity of this sensibilization seems of value for predicting the duration of the graft's survival.
控制肾移植的关键在于了解免疫反应。通过供体HL - A抗原致敏释放的细胞免疫机制对急性排斥反应尤为重要。为了预测排斥危机并启动强化免疫抑制措施，了解细胞免疫反应的程度很重要。在实验中，通过MEM试验，使用从供体脾脏或肾脏分离的移植抗原来证明致敏情况。在所有患者中都证实了对供体抗原的致敏性增加。这种致敏的速度似乎对预测移植物存活时间有价值。
