Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China.
Genes Immun. 2023 Oct;24(5):220-235. doi: 10.1038/s41435-023-00216-9. Epub 2023 Aug 7.
Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal immune regulation, leading to damage to host organs. The complicated pathogenesis and varied clinical symptoms of AIDs pose great challenges in diagnosing and monitoring this disease. Regrettably, the etiological factors and pathogenesis of AIDs are still not completely understood. It is noteworthy that the development of single-cell RNA sequencing (scRNA-seq) technology provides a new tool for analyzing the transcriptome of AIDs. In this essay, we have summarized the development of scRNA-seq technology, and made a relatively systematic review of the current research progress of scRNA-seq technology in the field of AIDs, providing a reference to preferably understand the pathogenesis, diagnosis, and treatment of AIDs.
自身免疫性疾病（AIDs）是由免疫耐受缺陷或免疫调节异常引起的，导致宿主器官受损。AIDs 的复杂发病机制和多样的临床症状给疾病的诊断和监测带来了巨大挑战。遗憾的是，AIDs 的病因和发病机制仍不完全清楚。值得注意的是，单细胞 RNA 测序（scRNA-seq）技术的发展为分析 AIDs 的转录组提供了新的工具。在本文中，我们总结了 scRNA-seq 技术的发展，并对 scRNA-seq 技术在 AIDs 领域的研究进展进行了较为系统的综述，为更好地了解 AIDs 的发病机制、诊断和治疗提供了参考。
