Beni Zahra Naderi, Beni Afsaneh Naderi, Samani Fereidoun Rahmani, Dayani Mohammad Ali, Beni Fariba Naderi, Radmehr Hamed, Noorshargh Pegah
Shahrekord University of Medical Sciences, Shahr-e Kord, Chaharmahal and Bakhtiari Province 88167-54633, Iran.
Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan 81496-44874, Iran.
Asian Biomed (Res Rev News). 2022 Feb 28;16(1):31-42. doi: 10.2478/abm-2022-0005. eCollection 2022 Feb.
Few reports have addressed the clinical and laboratory features of patients with coronavirus disease-2019 (COVID-19) in mountainous areas, especially in Iran.
To report the clinical and laboratory data and manifestations predicting mortality of patients with COVID-19 in the west of Iran.
We conducted a retrospective cohort study of 286 patients hospitalized with COVID-19 between 25 February 2020 and 12 May 2020 to describe their clinical symptoms and laboratory test findings when they were admitted at the Hajar Hospital affiliated with the Shahrekord University of Medical Sciences, and a multivariable analysis of factors that predict their disease severity and mortality.
After hospital admission, 18 patients died and 268 were discharged. Older age [odds ratio (OR) = 1.02, 95% confidence interval (CI) = 1.01-1.04, = 0.001], presence of underlying diseases (OR = 1.86, 95% CI = 1.01-3.45, = 0.04), elevated hematocrit (OR = 1.08, 95% CI = 1.03-1.13, = 0.002), and increase in red blood cell distribution width (RDW) coefficient of variation (OR = 1.18, 95% CI = 1.02-1.36, = 0.02) were significantly associated with disease severity. Older age (OR = 1.00, 95% CI = 1.00-1.07, = 0.03), hypocalcemia (OR = 0.20, 95% CI = 0.09-0.58, = 0.002), hypophosphatemia (OR = 0.50, 95% CI = 0.26-1.02, = 0.04), and increase in platelet-larger cell ratio (P-LCR; OR = 1.10, 95% CI = 1.00-1.15, = 0.04) were significantly associated with mortality. The areas under the receiver operating characteristic curves were as follows: calcium 0.759; lactate dehydrogenase (LDH) 0.731; phosphorus 0.725; bilirubin 0.689; C-reactive protein 0.679; and RDW - standard deviation (RDW-SD) 0.624.
Those who did not survive tended to be elderly and had a greater incidence of comorbidities. Elevated LDH, decreased levels of calcium and phosphorus, and anemia at diagnosis were associated with greater risk of death for these Iranian patients hospitalized with COVID-19. Regular assessment of these markers would help to manage patients with COVID-19.
关于2019冠状病毒病（COVID-19）患者在山区尤其是伊朗的临床和实验室特征的报道较少。
报告伊朗西部COVID-19患者的临床和实验室数据以及预测死亡的表现。
我们对2020年2月25日至2020年5月12日期间因COVID-19住院的286例患者进行了一项回顾性队列研究，以描述他们在设拉子医科大学附属哈贾尔医院入院时的临床症状和实验室检查结果，并对预测其疾病严重程度和死亡率的因素进行多变量分析。
入院后，18例患者死亡，268例出院。年龄较大[比值比（OR）=1.02，95%置信区间（CI）=1.01-1.04，P=0.001]、存在基础疾病（OR=1.86，95%CI=1.01-3.45，P=0.04）、血细胞比容升高（OR=1.08，95%CI=1.03-1.13，P=0.002）以及红细胞分布宽度（RDW）变异系数增加（OR=1.18，95%CI=1.02-1.36，P=0.02）与疾病严重程度显著相关。年龄较大（OR=1.00，95%CI=1.00-1.07，P=0.03）、低钙血症（OR=0.20，95%CI=0.09-0.58，P=0.002）、低磷血症（OR=0.50，95%CI=0.26-1.02，P=0.04）以及血小板大细胞比率（P-LCR）增加（OR=1.10，95%CI=1.00-1.15，P=0.04）与死亡率显著相关。受试者工作特征曲线下面积如下：钙0.759；乳酸脱氢酶（LDH）0.731；磷0.725；胆红素0.689；C反应蛋白0.679；以及RDW-标准差（RDW-SD）0.624。
未能存活的患者往往年龄较大且合并症发生率更高。这些因COVID-19住院的伊朗患者，诊断时LDH升高、钙和磷水平降低以及贫血与更高的死亡风险相关。定期评估这些指标将有助于管理COVID-19患者。
