Ben Belgacem Hajer, Bouguila Jihene, Tej Amel, Tilouche Samia, Kebaili Raoudha, Kahloul Najoua, Barbouche Mohamed Ridha, Soyah Nejla, Boughammoura Lamia
Tunis Med. 2022;100(12):881-886.
Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in Tunisia, can lead to serious complications ranging from local disease to disseminated disease in a group of patients with primary immunodeficiency diseases.
A 3-month-old boy presented with persistent fever, hepato-splenomegaly and multiple osteolytic lesions. He was diagnosed with severe combined immunodeficiency disease and disseminated BCG infection. Despite anti-tubercular therapy combined with intravenous immunoglobulin, the evolution was fatal.
The case highlights the possible risk of such rare yet lethal complication of BCG vaccine. In suspected cases of primary immunodeficiency disease, inoculation of BCG should be postponed until appropriate screening tests exclude such diagnosis to prevent serious complications.
在突尼斯，所有新生儿都接种卡介苗（BCG），在一组原发性免疫缺陷病患者中，卡介苗可导致从局部疾病到播散性疾病等严重并发症。
一名3个月大的男婴出现持续发热、肝脾肿大和多处溶骨性病变。他被诊断为重症联合免疫缺陷病和播散性卡介苗感染。尽管采用了抗结核治疗并联合静脉注射免疫球蛋白，但病情仍发展至致命结局。
该病例凸显了卡介苗这种罕见但致命并发症的潜在风险。在疑似原发性免疫缺陷病的病例中，应推迟接种卡介苗，直到适当的筛查试验排除该诊断，以预防严重并发症。
