Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Shenzhen Nanshan Maternity and Child Healthcare Hospital, Shenzhen, China.
Food Funct. 2023 Aug 29;14(17):7938-7945. doi: 10.1039/d3fo01853a.
: Previous studies on prenatal polyunsaturated fatty acids (PUFAs) and children's neurodevelopment have shown inconsistent results, and evidence from the Asian population is scarce. : To investigate the association between maternal erythrocyte PUFAs and neurodevelopment in children in the Chinese population. : We included 242 mother-child pairs from the Yuexiu birth cohort. The composition of maternal erythrocyte fatty acids during pregnancy was measured by gas chromatography. Each PUFA was divided into 3 tertiles. Neurodevelopment in children was evaluated with the Ages and Stages Questionnaire at 2 years of age, including 5 domains of development: communication, gross motor, fine motor, problem solving, and personal-social skills. : Maternal eicosapentaenoic acid (EPA) [OR (95% CI): 0.34 (0.15, 0.74) for tertile 2, and 0.31 (0.13, 0.70) for tertile 3] was associated with a reduced risk of potential developmental delay in gross motor skills. Conversely, arachidonic acid (AA) [OR (95% CI): 2.54 (1.17, 5.70) for tertile 3] was associated with an increased risk of potential developmental delay in personal-social skills. The ratio of AA/EPA [OR (95% CI): 2.64 (1.18, 6.15) for tertile 3] was associated with an increased risk of potential developmental delay in gross motor skills. No significant association was found between other PUFAs and neurodevelopment. : This birth cohort has first shown a beneficial association between maternal EPA and gross motor skills of children. Meanwhile, maternal AA and the ratio of AA/EPA have negative associations with neurodevelopment in children.
: 先前关于产前多不饱和脂肪酸（PUFAs）和儿童神经发育的研究结果并不一致，亚洲人群的证据也很少。: 本研究旨在调查中国人群中母亲红细胞 PUFAs 与儿童神经发育之间的关系。: 我们纳入了来自越秀出生队列的 242 对母婴。孕期母亲红细胞脂肪酸组成采用气相色谱法测定。将每种多不饱和脂肪酸分为 3 个三分位组。儿童神经发育在 2 岁时采用年龄和阶段问卷进行评估，包括沟通、大运动、精细运动、解决问题和个人-社会技能 5 个发育领域。: 母亲二十碳五烯酸（EPA）[比值比（95%置信区间）：三分位 2 组为 0.34（0.15，0.74），三分位 3 组为 0.31（0.13，0.70）]与大运动技能潜在发育迟缓的风险降低相关。相反，花生四烯酸（AA）[比值比（95%置信区间）：三分位 3 组为 2.54（1.17，5.70）]与个人-社会技能潜在发育迟缓的风险增加相关。AA/EPA 比值[比值比（95%置信区间）：三分位 3 组为 2.64（1.18，6.15）]与大运动技能潜在发育迟缓的风险增加相关。其他 PUFAs 与神经发育之间没有显著关联。: 本出生队列首次表明，母亲 EPA 与儿童大运动技能之间存在有益关联。同时，母亲 AA 和 AA/EPA 比值与儿童神经发育呈负相关。
