Antimicrobial Defence Laboratory, The Francis Crick Institute , London, UK.
J Exp Med. 2023 Sep 4;220(9). doi: 10.1084/jem.20230783. Epub 2023 Aug 8.
Microbial dysbiosis triggers inflammatory periodontitis. In this issue of JEM, Kim et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221751) demonstrate that neutrophil extracellular trap histones are the major mediators fueling the pathogenic Th17 inflammation that promotes gum and bone loss in periodontitis.
微生物失调引发炎症性牙周炎。在本期《实验医学杂志》中，Kim 等人（2023. J. Exp. Med.https://doi.org/10.1084/jem.20221751）表明中性粒细胞胞外诱捕网组蛋白是主要的介质，它促进了促炎性 Th17 炎症，从而导致牙周炎中的牙龈和骨丧失。
