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新型肉瘤免疫治疗策略:2023 年 ASCO 年会要点。

New immunotherapy strategies for patients with sarcomas: highlights from the 2023 ASCO annual meeting.

机构信息

DITEP, Gustave Roussy, Villejuif, France.

Department of Medicine, Institut Bergonié, 229 Cours de l'Argonne, 33000, Bordeaux, France.

出版信息

J Hematol Oncol. 2023 Aug 8;16(1):93. doi: 10.1186/s13045-023-01486-6.

DOI:10.1186/s13045-023-01486-6
PMID:37553669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10408188/
Abstract

Immunotherapy has revolutionized cancer treatment, but currently, immuno-oncology agents have not been approved for patients with soft tissue sarcomas. However, there is growing evidence suggesting that immunotherapy could be an effective therapeutic strategy for this group of diseases. Here, we reviewed the latest advances of immunotherapy trials from the 2023 American Society of Clinical Oncology Annual Meeting, including some novel and encouraging combination regimens. Further research is still needed to fully understand the optimal use of these agents in sarcoma treatment.

摘要

免疫疗法已经彻底改变了癌症治疗方法,但目前,免疫肿瘤药物尚未获批用于软组织肉瘤患者。然而,越来越多的证据表明,免疫疗法可能是治疗这类疾病的有效策略。在这里,我们回顾了 2023 年美国临床肿瘤学会年会的免疫治疗试验的最新进展,包括一些新颖且令人鼓舞的联合治疗方案。仍需要进一步的研究来充分了解这些药物在肉瘤治疗中的最佳应用。

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本文引用的文献

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Nat Med. 2022 Jun;28(6):1199-1206. doi: 10.1038/s41591-022-01821-3. Epub 2022 May 26.
2
PD1/PD-L1 targeting in advanced soft-tissue sarcomas: a pooled analysis of phase II trials.PD1/PD-L1 靶向治疗晚期软组织肉瘤的疗效:两项 II 期临床试验的汇总分析。
J Hematol Oncol. 2020 May 19;13(1):55. doi: 10.1186/s13045-020-00891-5.
3
Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy.蒽环类药物与抗 CD47 治疗联合抑制浸润性乳腺癌生长,同时通过自噬调控预防心脏毒性。
Breast Cancer Res Treat. 2018 Nov;172(1):69-82. doi: 10.1007/s10549-018-4884-x. Epub 2018 Jul 28.
4
Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials.纳武利尤单抗联合或不联合伊匹单抗治疗转移性肉瘤(Alliance A091401):两项开放标签、非比较、随机、2 期临床试验。
Lancet Oncol. 2018 Mar;19(3):416-426. doi: 10.1016/S1470-2045(18)30006-8. Epub 2018 Jan 19.
5
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