Cao Rongkai, Chen Beibei, Song Kun, Guo Fang, Pan Haoxin, Cao Yujie
Stomatological Hospital and Dental School of Tongji University, Shanghai, China.
Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Front Med (Lausanne). 2023 Jul 24;10:1235992. doi: 10.3389/fmed.2023.1235992. eCollection 2023.
As a thin fibrous layer covering the bone surface, the periosteum plays a significant role in bone physiology during growth, development and remodeling. Over the past several decades, the periosteum has received considerable scientific attention as a source of mesenchymal stem cells (MSCs). Periosteum-derived cells (PDCs) have emerged as a promising strategy for tissue engineering due to their chondrogenic, osteogenic and adipogenic differentiation capacities. Starting from the history of PDCs, the present review provides an overview of their characterization and the procedures used for their isolation. This study also summarizes the chondrogenic, osteogenic, and adipogenic abilities of PDCs, serving as a reference about their potential therapeutic applications in various clinical scenarios, with particular emphasis on the comparison with other common sources of MSCs. As techniques continue to develop, a comprehensive analysis of the characterization and regulation of PDCs can be conducted, further demonstrating their role in tissue engineering. PDCs present promising potentials in terms of their osteogenic, chondrogenic, and adipogenic capacities. Further studies should focus on exploring their utility under multiple clinical scenarios to confirm their comparative benefit over other commonly used sources of MSCs.
骨膜作为覆盖骨表面的一层薄纤维组织，在骨骼的生长、发育和重塑过程中的生理功能中发挥着重要作用。在过去几十年里，骨膜作为间充质干细胞（MSCs）的来源受到了广泛的科学关注。由于其具有向软骨、成骨和脂肪细胞分化的能力，来源于骨膜的细胞（PDCs）已成为组织工程领域一种有前景的策略。从PDCs的历史开始，本综述概述了它们的特征以及用于分离它们的程序。本研究还总结了PDCs的软骨生成、成骨和脂肪生成能力，为其在各种临床情况下的潜在治疗应用提供参考，特别强调了与其他常见MSCs来源的比较。随着技术不断发展，可以对PDCs的特征和调控进行全面分析，进一步证明它们在组织工程中的作用。PDCs在成骨、软骨生成和脂肪生成能力方面具有广阔的应用前景。进一步的研究应集中在探索它们在多种临床情况下的效用，以确认它们相对于其他常用MSCs来源的比较优势。
