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伴有绒毛高度/隐窝深度比值显著降低的短暂性非乳糜泻麸质敏感性（NCGS）。

Transient non-coeliac gluten sensitivity (NCGS) with markedly reduced villous height/crypt depth ratio.

作者信息

Williams Charlotte, Smith Nicole, Rostami Kamran

机构信息

Department of Gastroenterology, MidCentral DHB, Palmerston North, New Zealand.

Department of Pathology, MidCentral DHB, Palmerston North, New Zealand.

出版信息

Gastroenterol Hepatol Bed Bench. 2023;16(2):222-224. doi: 10.22037/ghfbb.v16i2.2755.

DOI:10.22037/ghfbb.v16i2.2755
PMID:37554753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10404823/
Abstract

There is no confident evidence in the current literature to show or demonstrate that non-coeliac gluten sensitivity (NCGS) exclusively presents with mild or nearly normal duodenal mucosal abnormality. Gluten sensitive patients with negative serology and severe mucosal changes are labelled with the term seronegative coeliac disease (SNCS). There might be at least some overlap between NCGS and SNCD. Transient gluten sensitivity with severe mucosal changes without CD have been previously reported like in our case.

摘要

目前的文献中没有确凿证据表明非乳糜泻性麸质敏感（NCGS）仅表现为轻度或近乎正常的十二指肠黏膜异常。血清学阴性且黏膜有严重改变的麸质敏感患者被称为血清阴性乳糜泻（SNCS）。NCGS和SNCD之间可能至少存在一些重叠。此前已有报道，如我们的病例所示，存在无乳糜泻但有严重黏膜改变的短暂性麸质敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5061/10404823/685fdb1dfcee/GHFBB-16-222-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5061/10404823/685fdb1dfcee/GHFBB-16-222-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5061/10404823/685fdb1dfcee/GHFBB-16-222-g001.jpg

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Transient non-coeliac gluten sensitivity (NCGS) with markedly reduced villous height/crypt depth ratio.伴有绒毛高度/隐窝深度比值显著降低的短暂性非乳糜泻麸质敏感性（NCGS）。
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本文引用的文献

1
Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study. gluten 诱导非乳糜泻麸质敏感性患者十二指肠黏膜的细微组织学变化：一项多中心研究。
Nutrients. 2022 Jun 15;14(12):2487. doi: 10.3390/nu14122487.
2
Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity.非乳糜泻小麦敏感患者的十二指肠和直肠黏膜炎症。
Clin Gastroenterol Hepatol. 2019 Mar;17(4):682-690.e3. doi: 10.1016/j.cgh.2018.08.043. Epub 2018 Aug 21.
3
Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet.
血清阴性乳糜泻患者的临床和基因特征：自然病史及对无麸质饮食的反应
BMJ Open Gastroenterol. 2017 Jul 17;4(1):e000159. doi: 10.1136/bmjgast-2017-000159. eCollection 2017.
4
Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease.在无乳糜泻的情况下报告对小麦敏感的个体中肠道细胞损伤和全身免疫激活。
Gut. 2016 Dec;65(12):1930-1937. doi: 10.1136/gutjnl-2016-311964. Epub 2016 Jul 25.
5
Rebutting Oberhuber- Again.再次反驳奥伯胡伯。
Gastroenterol Hepatol Bed Bench. 2015 Fall;8(4):303-5.
6
Spectrum of gluten-related disorders: consensus on new nomenclature and classification.麸质相关疾病谱：新命名与分类共识。
BMC Med. 2012 Feb 7;10:13. doi: 10.1186/1741-7015-10-13.
7
Transient gluten intolerance.短暂性麸质不耐受
Arch Dis Child. 1970 Aug;45(242):523-6. doi: 10.1136/adc.45.242.523.
8
Incidence of coeliac disease and transient gluten intolerance in children in a Swedish urban community.瑞典一个城市社区儿童腹腔疾病和短暂性麸质不耐受的发病率。
Acta Paediatr Scand. 1979 May;68(3):397-400. doi: 10.1111/j.1651-2227.1979.tb05026.x.