Hasan Yasmeen Kamel, Alsultan Mohammad, Anan Mohamed Taher, Hassn Qussai, Basha Kassem
Department of Nephrology, Al Assad and Al Mouwasat University Hospitals.
Department of Statics, Aleppo University-Faculty of Sciences, Aleppo, Syria.
Ann Med Surg (Lond). 2023 Jun 5;85(8):3838-3844. doi: 10.1097/MS9.0000000000000931. eCollection 2023 Aug.
Dyslipidemia is an established risk factor for cardiovascular disease (CVD), which is the main cause of mortality among haemodialysis (HD) patients. We investigate the prevalence and characteristics of dyslipidemia in HD patients. Also, we aimed to study the prediction scores; Framingham risk score (FRS), and the atherosclerotic cardiovascular disease risk score; among this population.
One hundred fifty-three HD patients were enroled in this retrospective cross-sectional study from two HD centres in Syria, from March 2021 to March 2022. Dyslipidemia is considered as follows; hyper-total cholesterol (TC) (≥200 mg/dl), hyper-triglycerides (TG), (≥150 mg/dl), hyper-low-density lipoprotein (LDL) (≥100 mg/dl), hypo-high-density lipoprotein (HDL) (<40 mg/dl), hyper-Non-HDL (≥130 mg/dl).
The most prevalent dyslipidemic parameter was low HDL (72.50%) followed by increased TGs (37.30%). TC, LDL, HDL, and Non-HDL showed differences between males and females (=0.001, 0.015, 0.024, and 0.025; respectively). These parameters were higher in females. History of CVD showed associations with TC, LDL, HDL, and non-HDL (=0.003, 0.007, 0.004, and 0.004; respectively). Additionally, statins showed effects on TC, LDL, and non-HDL (=0.003, 0.0002, and 0.002; respectively); however, no relation with TG and HDL (=0.9 and 0.4). HDL level showed differences in low (7.5%) and intermediate (10%) FRS (=0.01 and 0.028; respectively); however, it did not show a difference in high (20%) FRS (=0.68). The lipids profile did not show differences in different thresholds of atherosclerotic cardiovascular disease scores.
The prevalence of dyslipidemia was high in HD patients in Syria. All lipid parameters except TG showed differences between males and females. Comparisons of lipid parameters with CVD risk stratifications support the need for further studies to prove the benefits of these scores in CVD prediction among the dialysis population.
血脂异常是心血管疾病（CVD）的既定危险因素，而心血管疾病是血液透析（HD）患者死亡的主要原因。我们调查了HD患者血脂异常的患病率和特征。此外，我们旨在研究预测评分；弗明汉风险评分（FRS）和动脉粥样硬化性心血管疾病风险评分；在这一人群中的情况。
2021年3月至2022年3月，从叙利亚的两个HD中心招募了153例HD患者进行这项回顾性横断面研究。血脂异常的定义如下；总胆固醇（TC）升高（≥200mg/dl）、甘油三酯（TG）升高（≥150mg/dl）、低密度脂蛋白（LDL）升高（≥100mg/dl）、高密度脂蛋白（HDL）降低（<40mg/dl）、非HDL升高（≥130mg/dl）。
最常见的血脂异常参数是HDL降低（72.50%），其次是TG升高（37.30%）。TC、LDL、HDL和非HDL在男性和女性之间存在差异（分别为=0.001、0.015、0.024和0.025）。这些参数在女性中更高。CVD病史与TC、LDL、HDL和非HDL相关（分别为=0.003、0.007、0.004和0.004）。此外，他汀类药物对TC、LDL和非HDL有影响（分别为=0.003、0.0002和0.002）；然而，与TG和HDL无关（分别为=0.9和0.4）。HDL水平在低（7.5%）和中（10%）FRS组中存在差异（分别为=0.01和0.028）；然而，在高（20%）FRS组中未显示差异（=0.68）。血脂谱在动脉粥样硬化性心血管疾病评分的不同阈值之间未显示差异。
叙利亚HD患者中血脂异常的患病率很高。除TG外，所有血脂参数在男性和女性之间均存在差异。将血脂参数与CVD风险分层进行比较，支持需要进一步研究以证明这些评分在透析人群CVD预测中的益处。
