Gu Dongqing, Ou Shan, Liu Guodong
Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Department of Anesthesiology, First People's Hospital of Chengdu, Chengdu, China.
Front Psychiatry. 2023 Jul 24;14:1152005. doi: 10.3389/fpsyt.2023.1152005. eCollection 2023.
Trauma has been proposed as a risk factor for the development of psychiatric disorders. This study aimed to determine the causal role of trauma in six common psychiatric disorders.
We obtained summary-level data for genetic variants associated with trauma and the corresponding association with psychiatric disorders from previous genome-wide association studies. Two-sample Mendelian randomization analyzes were performed to estimate the causal association between trauma and psychiatric disorders, with inverse variance weighted used as the main method.
Genetically predisposed trauma was associated with an increased risk of psychiatric disorders [odds ratio (OR) =1.24, 95%, confidence interval (CI), 1.09-1.40], anxiety disorder (OR = 1.30, 95% CI, 1.10-1.52) and schizophrenia (OR = 1.48, 95% CI, 1.18-1.84). However, the associations between trauma and sleep disorder (OR = 1.17, 95% CI, 1.01-1.35), as well as depression (OR = 1.09, 95% CI, 1.02-1.16) did not reach a Bonferroni corrected significance level. Besides, no association was observed between trauma and risk of bipolar disorder (OR = 1.21, 95% CI, 0.98-1.48) and eating disorder (OR = 1.28, 95% CI, 0.88-1.86).
Trauma might be causally associated with an increased risk of some common psychiatric disorders such as anxiety disorder and schizophrenia. However, little evidence supported an association between trauma and risk of depression, bipolar disorder, sleep disorder, and eating disorder. Our findings offered novel insights into the trauma-mediated development mechanism of psychiatric disorders, and psychological intervention to patients with trauma may be an effective prevention strategy for psychological diseases.
创伤已被认为是精神疾病发生的一个风险因素。本研究旨在确定创伤在六种常见精神疾病中的因果作用。
我们从先前的全基因组关联研究中获得了与创伤相关的基因变异的汇总水平数据以及与精神疾病的相应关联。进行了两样本孟德尔随机化分析以估计创伤与精神疾病之间的因果关联，主要方法采用逆方差加权法。
遗传易感性创伤与精神疾病风险增加相关[比值比（OR）=1.24，95%置信区间（CI），1.09 - 1.40]、焦虑症（OR = 1.30，95% CI，1.10 - 1.52）和精神分裂症（OR = 1.48，95% CI，1.18 - 1.84）。然而，创伤与睡眠障碍（OR = 1.17，95% CI，1.01 - 1.35）以及抑郁症（OR = 1.09，95% CI，1.02 - 1.16）之间的关联未达到Bonferroni校正的显著性水平。此外，未观察到创伤与双相情感障碍风险（OR = 1.21，95% CI，0.98 - 1.48）和进食障碍（OR = 1.28，95% CI，0.88 - 1.86）之间存在关联。
创伤可能与某些常见精神疾病如焦虑症和精神分裂症的风险增加存在因果关联。然而，几乎没有证据支持创伤与抑郁症、双相情感障碍、睡眠障碍和进食障碍风险之间存在关联。我们的研究结果为精神疾病的创伤介导发展机制提供了新的见解，对创伤患者的心理干预可能是预防心理疾病的有效策略。
