Gale R, Vreman H J, Ferguson J E, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, Calif.
Biol Neonate. 1988;54(1):45-8. doi: 10.1159/000242822.
The rate of bilirubin production was studied in 12-hour-old rats exposed to bupivacaine HCl by subcutaneous injection. The bilirubin production was estimated by measuring the excretion rate of carbon monoxide (VeCO) using an open flow-through system. No significant difference was found between the VeCO of bupivacaine HCl-treated and control animals, or between the levels of bilirubin in the pooled blood of treated (0.92 +/- 0.32 SE mg/dl) and control (1.0 +/- 0.28 SE mg/dl) animals. These negative findings support the clinical studies which have not demonstrated an association between epidural anesthesia with bupivacaine HCl and neonatal jaundice.
通过皮下注射给予盐酸布比卡因，研究12小时龄大鼠的胆红素生成速率。使用开放流通系统通过测量一氧化碳排泄率（VeCO）来估计胆红素生成。盐酸布比卡因处理组和对照组动物的VeCO之间，以及处理组（0.92±0.32标准误mg/dl）和对照组（1.0±0.28标准误mg/dl）动物混合血液中的胆红素水平之间，均未发现显著差异。这些阴性结果支持了临床研究，这些研究未证明盐酸布比卡因硬膜外麻醉与新生儿黄疸之间存在关联。
