Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Department of Gastroenterology, Asahi University Hospital, Gifu, Japan.
BMC Endocr Disord. 2020 Jul 24;20(1):113. doi: 10.1186/s12902-020-00581-w.
Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC.
We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC.
During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00-1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637-737, sensitivity = 0.620, specificity = 0.668, p < 0.001)).
TyG index can predict the onset of CRC. For early detection of CRC, we should encourage people with high TyG index to undergo screening for CRC.
结直肠癌（CRC）与胰岛素抵抗有关，是最常见的癌症之一。甘油三酯-葡萄糖指数（TyG 指数）是胰岛素抵抗的标志物之一。我们进行了 TyG 指数与 CRC 发病风险之间的相关性研究。
我们在这项对 27944 名参与者（16454 名男性和 11490 名女性）的历史队列研究中，检验了 TyG 指数对 CRC 发病的影响。TyG 指数通过计算空腹甘油三酯（mg/dL）与空腹血糖（mg/dL）的乘积的自然对数值得出。使用 Cox 比例风险模型，通过性别、年龄、体重指数、吸烟状态、饮酒、运动、收缩压和肌酐调整 TyG 指数对 CRC 发病的影响。计算协变量调整后的接收者操作特征（ROC）曲线的曲线下面积（AUC）和 TyG 指数用于 CRC 发病的截断值。
在中位数为 4.4 年的随访期间，有 116 名参与者被诊断为 CRC。CRC 的累积发病率为 0.4%。在 Cox 比例风险模型中，在调整协变量后，TyG 指数的 HRs 为 1.38（95%置信区间（CI），1.00-1.91，p=0.049）。在协变量调整的 ROC 曲线分析中，TyG 指数预测 CRC 发病的截断值为 8.272（AUC 为 0.687（95%CI，0.637-737），敏感性为 0.620，特异性为 0.668，p<0.001）。
TyG 指数可以预测 CRC 的发病。为了早期发现 CRC，我们应该鼓励 TyG 指数较高的人群进行 CRC 筛查。
