4-烷基-1,4-二氢吡啶的合成：铁（II）介导的环醚与烯胺酮的氧化级联环化反应
Synthesis of 4-Alkylated 1,4-Dihydropyridines: Fe(II)-Mediated Oxidative Cascade Cyclization Reaction of Cyclic Ethers with Enaminones.
作者信息
Sun Yulin, Liu Zhuoyuan, Liu Donghan, Zhang Mingshuai, Chen Longkun, Chai Zhangmengjie, Chen Xue-Bing, Yu Fuchao
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China.
College of Science, Honghe University, Mengzi 661199 Yunnan, P. R. China.
出版信息
J Org Chem. 2023 Aug 18;88(16):11627-11636. doi: 10.1021/acs.joc.3c00925. Epub 2023 Aug 9.
Syntheses of highly functionalized 4-alkylated 1,4-dihydropyridines (1,4-DHPs) from cyclic ethers and enaminones via iron(II)-mediated oxidative free radical cascade C(sp)-H bond functionalization/C(sp)-O bond cleavage/cyclization reaction have been first developed. This novel synthetic strategy offers an alternative method for the construction of 1,4-DHPs by using esters as the C4 sources, as well as expands the application of ethers in heterocycle synthesis.
首次开发了通过铁（II）介导的氧化自由基级联C（sp）-H键官能团化/C（sp）-O键裂解/环化反应，从环醚和烯胺酮合成高官能团化的4-烷基化1,4-二氢吡啶（1,4-DHPs）。这种新颖的合成策略提供了一种以酯作为C4源构建1,4-DHPs的替代方法，同时也扩展了醚在杂环合成中的应用。
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