Perinatal and Cardiovascular Epidemiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden; Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
EBioMedicine. 2023 Sep;95:104750. doi: 10.1016/j.ebiom.2023.104750. Epub 2023 Aug 8.
Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.
Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.
We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.
The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.
Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.
室外温度与死亡率和水合状态有关，而通过替代物 copeptin 测量的血管加压素是心血管代谢风险和水合的标志物。我们最近表明，copeptin 具有季节性模式，冬季血浆浓度较高。在这里，我们旨在研究室外温度与 copeptin 之间的关系。
在瑞典马尔默的五个队列的空腹血浆中分析了 copeptin（n=26753，49.7%男性，年龄 18-86 岁）。我们使用了带有四个结的多变量调整非线性样条模型来研究短期温度（24 小时平均表观温度）和 log copeptin z 分数之间的关系。
我们发现温度与 log copeptin z 分数之间存在明显的非线性关系，中等低温和高温均与较高的 copeptin 浓度相关（p<0.0001）。在 0°C 和第 75 个温度百分位数的最低点（对应于 14.3°C）之间，log copeptin 降低了 0.13 个 z 分数（95%CI 0.096; 0.16），这也对应于最低点和 21.3°C 之间 log copeptin z 分数的增加。
短期温度和 copeptin 之间的 J 形关系类似于温度和死亡率之间的 J 形关系。虽然需要进一步研究将温度与水合的其他季节性影响分开，但适度增加水摄入量是降低血管加压素的可行干预措施，可能减轻中度寒冷和炎热的室外温度对健康的不利影响。
瑞典研究委员会、Å Wiberg、M Stephen、A Påhlsson、Crafoord 基金会和瑞典心脏肺基金会、瑞典医学研究协会和瑞典医学协会。
