Yokochi T, Nakashima I, Kato N, Asai J, Miyadai T, Kimura Y
Microbiol Immunol. 1986;30(6):553-9. doi: 10.1111/j.1348-0421.1986.tb02981.x.
The role of humoral and cellular immune responses in the initiation and maintenance of autoimmune thyroiditis was investigated in mice immunized with syngeneic thyroid extract and Klebsiella O3 lipopolysaccharide (KO3 LPS) as an adjuvant. The transfer of spleen cells from hyperimmunized mice to 400R-irradiated syngeneic mice produced definite lesions in the thyroid glands, whereas the transfer of immune sera failed to do so. No lesions were induced in normal intact mice by the same transfer of sera and spleen cells from hyperimmunized mice. It was suggested that the induction of thyroiditis by immunization using KO3 LPS adjuvant is primarily due to cell-mediated immunity and that pretreatment of mice by X-irradiation is essential for production of the lesions. The role of X-irradiation in the induction of thyroiditis was discussed.
在用同基因甲状腺提取物和肺炎克雷伯菌O3脂多糖（KO3 LPS）作为佐剂免疫的小鼠中，研究了体液免疫和细胞免疫反应在自身免疫性甲状腺炎的引发和维持中的作用。将来自高度免疫小鼠的脾细胞转移到经400R照射的同基因小鼠中，会在甲状腺中产生明确的病变，而免疫血清的转移则不会。来自高度免疫小鼠的相同血清和脾细胞转移，不会在正常完整小鼠中诱导病变。有人提出，使用KO3 LPS佐剂进行免疫诱导甲状腺炎主要是由于细胞介导的免疫，并且小鼠的X射线预处理对于病变的产生至关重要。讨论了X射线照射在甲状腺炎诱导中的作用。
