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以甘露糖同多糖作为O-特异性多糖的脂多糖对小鼠非免疫原性自身抗原免疫反应的新型佐剂作用。

Novel adjuvant action of lipopolysaccharides that possess mannose homopolysaccharides as O-specific polysaccharides on immune responses to nonimmunogenic autoantigens in mice.

作者信息

Yokochi T, Fukada M, Kawai M, Zhang Y H, Jiang G Z, Takahashi K

机构信息

Department of Microbiology, Aichi Medical University School of Medicine, Japan.

出版信息

Infect Immun. 1992 Nov;60(11):4953-6. doi: 10.1128/iai.60.11.4953-4956.1992.

DOI:10.1128/iai.60.11.4953-4956.1992
PMID:1383160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258254/
Abstract

The adjuvant action of various lipopolysaccharides on immune responses to syngeneic tissue extract in mice was examined. Only lipopolysaccharides possessing the linear mannose homopolysaccharides as O-specific polysaccharides exhibited definite adjuvant action on immune responses to the autoantigens. The intensity of this adjuvant activity of lipopolysaccharide from Klebsiella O3 seemed to be the strongest.

摘要

研究了各种脂多糖对小鼠同基因组织提取物免疫反应的佐剂作用。只有以线性甘露糖同多糖作为O-特异性多糖的脂多糖对自身抗原的免疫反应表现出明确的佐剂作用。来自肺炎克雷伯菌O3的脂多糖的这种佐剂活性强度似乎最强。

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Augmented immunological activities of recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide.以甘露糖均聚物作为O-特异性多糖的重组脂多糖增强的免疫活性。
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3
A murine model of experimental autoimmune lens-induced uveitis using Klebsiella O3 lipopolysaccharide as a potent immunological adjuvant.一种以肺炎克雷伯菌O3脂多糖作为强效免疫佐剂的实验性自身免疫性晶状体诱导性葡萄膜炎的小鼠模型。
Int J Exp Pathol. 1993 Dec;74(6):573-82.
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