Gallo P V, Weinberg J
Alcohol. 1986 Jul-Aug;3(4):261-7. doi: 10.1016/0741-8329(86)90035-2.
Effects of perinatal exposure to ethanol on growth and cellular development were investigated. Alcohol was administered in liquid diets designed to provide optimal nutrition during pregnancy. Pair-fed and ad lib control groups were included. The 3 groups of females were similar in body weight during gestation and lactation, and offspring weights were similar on gestation Day 21 and at birth. By Day 9 of lactation control pups weighted more than both alcohol and pair-fed pups which were similar in body weight. Weights of brain, heart, liver and kidney were reduced in alcohol pups compared to pair-feds and controls. Decreased liver weight reflected both decreased cell size and decreased protein content, but was primarily due to decreased caloric intake. Decreased heart weight appeared to result from a direct effect of ethanol on heart protein content. Even more marked were the adverse effects of ethanol on kidney protein content and kidney DNA (reflecting a decrease in cell number). In contrast, although both absolute brain weight and DNA content were decreased in ethanol-exposed offspring, relative brain weight was increased. Finally, maternal ethanol consumption significantly increased relative placenta weights as well as placental DNA and protein content.
研究了围产期暴露于乙醇对生长和细胞发育的影响。在旨在孕期提供最佳营养的液体饮食中给予酒精。设立了配对喂养组和自由采食对照组。三组雌性动物在妊娠和哺乳期的体重相似，子代在妊娠第21天和出生时的体重也相似。到哺乳期第9天，对照组幼崽的体重比酒精组和配对喂养组的幼崽都要重，而酒精组和配对喂养组的幼崽体重相似。与配对喂养组和对照组相比，酒精组幼崽的脑、心脏、肝脏和肾脏重量减轻。肝脏重量的降低反映了细胞大小和蛋白质含量的降低，但主要是由于热量摄入减少。心脏重量的降低似乎是乙醇对心脏蛋白质含量直接作用的结果。乙醇对肾脏蛋白质含量和肾脏DNA的不利影响更为明显（反映细胞数量减少）。相比之下，尽管乙醇暴露后代的绝对脑重和DNA含量均降低，但相对脑重增加。最后，母体摄入乙醇显著增加了胎盘相对重量以及胎盘DNA和蛋白质含量。
