Pullen G L, Singh S P, Snyder A K
Department of Medicine, Chicago Medical School, IL.
Growth Dev Aging. 1988 Summer;52(2):85-9.
The role of altered glucose metabolism in the growth retardation associated with the Fetal Alcohol Syndrome has been difficult to assess because previously used experimental procedures have frequently substituted ethanol for dietary carbohydrate. Consequently, there is a severe reduction of the carbohydrate content of the diet. This study examined brain and liver development at 7, 15, 21, and 42 days of age in the male offspring of ethanol-fed rats which received a liquid diet in which carbohydrate and protein content were equal to that of the control diet. Ethanol provided 30% of the daily calories and was substituted isocalorically for fats. Body and liver weights of the offspring of these ethanol-fed rats were significantly lower than controls at all ages studied, and the mean brain weight was decreased at 7 and 15 days of age but not subsequently. Brain protein content was significantly lower in the experimental group at 7 and 15 days of age, and liver protein content was reduced at 15, 21, and 42 days of age. The DNA content was not affected in either organ by exposure to ethanol in utero. Increasingly carbohydrate and total caloric intake moderates, but does not eliminate, the effects of maternal ethanol ingestion on offspring growth.
由于先前使用的实验程序经常用乙醇替代膳食碳水化合物，因此难以评估葡萄糖代谢改变在胎儿酒精综合征相关生长发育迟缓中的作用。因此，饮食中的碳水化合物含量会大幅降低。本研究检测了乙醇喂养大鼠雄性后代在7、15、21和42日龄时的脑和肝脏发育情况，这些大鼠接受的液体饮食中碳水化合物和蛋白质含量与对照饮食相同。乙醇提供了30%的每日热量，并等热量地替代了脂肪。在所有研究的年龄阶段，这些乙醇喂养大鼠后代的体重和肝脏重量均显著低于对照组，且在7日龄和15日龄时平均脑重降低，但随后未再降低。实验组在7日龄和15日龄时脑蛋白含量显著降低，在15、21和42日龄时肝脏蛋白含量降低。子宫内接触乙醇对两个器官的DNA含量均无影响。碳水化合物和总热量摄入的增加可减轻但不能消除母体摄入乙醇对后代生长的影响。
