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围产期登革热的神经学表现

Neurological Manifestations of Perinatal Dengue.

作者信息

Singh Srijan, Alallah Jubara, Amrit Astha, Maheshwari Akhil, Boppana Suresh

机构信息

Department of Pediatrics, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.

Department of Pediatrics, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

出版信息

Newborn (Clarksville). 2023;2(2):158-172. doi: 10.5005/jp-journals-11002-0066. Epub 2023 May 7.

DOI:10.5005/jp-journals-11002-0066
PMID:37559696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10411360/
Abstract

Dengue viruses (DENVs) are single-stranded RNA viruses belonging to the family Flaviviridae. There are four distinct antigenically related serotypes, DENVs types 1, 2, 3, and 4. These are all mosquito-borne human pathogens. Congenital dengue disease occurs when there is mother-to-fetus transmission of the virus and should be suspected in endemic regions in neonates presenting with fever, maculopapular rash, and thrombocytopenia. Although most of the infected infants remain asymptomatic, some can develop clinical manifestations such as sepsis-like illness, gastric bleeding, circulatory failure, and death. Neurological manifestations include intracerebral hemorrhages, neurological malformations, and acute focal/disseminated encephalitis/encephalomyelitis. Dengue NS1Ag, a highly conserved glycoprotein, can help the detection of cases in the viremic stage. We do not have proven specific therapies yet; management is largely supportive and is focused on close monitoring and maintaining adequate intravascular volume.

摘要

登革病毒（DENVs）是属于黄病毒科的单链RNA病毒。有四种不同的抗原相关血清型，即1型、2型、3型和4型登革病毒。这些都是蚊媒传播的人类病原体。当病毒发生母婴传播时，就会出现先天性登革热疾病，在流行地区，对于出现发热、斑丘疹和血小板减少的新生儿应怀疑患有此病。虽然大多数受感染的婴儿没有症状，但有些婴儿会出现败血症样疾病、胃出血、循环衰竭和死亡等临床表现。神经学表现包括脑出血、神经畸形以及急性局灶性/播散性脑炎/脑脊髓炎。登革热非结构蛋白1抗原（Dengue NS1Ag）是一种高度保守的糖蛋白，有助于检测病毒血症阶段的病例。目前我们尚未有经过验证的特效疗法；治疗主要是支持性的，重点是密切监测和维持充足的血管内容量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/10411360/bc0f1f58d66e/nihms-1914674-f0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/10411360/6b556309412c/nihms-1914674-f0006.jpg
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