Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Neonatal Intensive Care Unit, 20122 Milan, Italy.
Nutrients. 2021 Feb 22;13(2):694. doi: 10.3390/nu13020694.
The anti-infective properties of breast milk have been known for decades. In recent years, an increasing number of papers have described the variety of bioactive compounds that are present in breast milk with varying degrees of antiviral activity. However, to date, the totality of the properties of these compounds is not fully understood and, above all, their synergistic interaction is not yet known. The purpose of this review is to describe the current knowledge about the antiviral compounds in breast milk, both with specific and non-specific action against pathogens. Due to the current pandemic situation from SARS-CoV-2 (Severe acute respiratory syndrome Coronavirus-2), research has focused on a multitude of potential antiviral substances, taking breast milk as a biological model of reference. Future research is needed to expand the knowledge of these compounds, which will hopefully assist in the development of therapies applicable even at later ages.
几十年来,人们一直都知道母乳具有抗感染特性。近年来,越来越多的论文描述了母乳中存在的多种具有不同程度抗病毒活性的生物活性化合物。然而,迄今为止,这些化合物的全部特性还没有被完全理解,尤其是它们的协同作用还不清楚。本文的目的是描述母乳中抗病毒化合物的现有知识,包括针对病原体的特异性和非特异性作用。由于目前 SARS-CoV-2(严重急性呼吸系统综合征冠状病毒-2)大流行的情况,研究集中在多种潜在的抗病毒物质上,以母乳作为生物参考模型。需要进一步研究来扩大对这些化合物的认识,希望这有助于开发甚至在后期年龄也适用的治疗方法。