Mo Daming, Guo Pengfei, Hu Shuwen, Tao Rui, Zhong Hui, Liu Huanzhong
Department of Psychiatry, Chao hu Hospital of Anhui Medical University, Hefei, China.
Department of Child and Adolescent Mental Disorder, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Front Psychiatry. 2023 Jul 25;14:1197854. doi: 10.3389/fpsyt.2023.1197854. eCollection 2023.
Adolescent patients with depressive disorders commonly exhibit somatic symptoms, which have a significant negative impact on their treatment and prognosis. Despite this, specific brain imaging characteristics of these symptoms have been poorly studied.
The Hamilton Depression Rating scale (HAMD-17), Children's Functional Somatization scale (CSI), and Toronto Alexithymia scale (TAS) were used to evaluate the clinical symptoms of adolescent depression. We analyzed the correlation between brain gray matter volume (GMV) and clinical symptoms in adolescent patients with depression and somatic symptoms.
The depression subgroups with and without functional somatic symptoms (FSS) had higher scores on the HAMD-17, CSI, and TAS than the normal control group. The group with FSS had higher HAMD-17, CSI, and TAS scores than the depression group without FSS ( < 0.05). CSI and TAS scores were positively correlated ( = 0.378, < 0.05). The GMV of the right supplementary motor area was higher in the depression groups with and without FSSs than in the normal control group, and the GMV was higher in the group without FSS than in the group with FSS ( = 29.394, < 0.05). The GMV of the right supplementary motor area was negatively correlated with CSI in the depressed group with FSS ( = -0.376, < 0.05). In the group with depression exhibiting FSS, CSI scores were positively correlated with GMV of the middle occipital gyrus ( = 0.665, = 0.0001), and TAS scores were positively correlated with GMV of the caudate nucleus ( = 0.551, = 0.001).
Somatic symptoms of adolescent depressive disorder are associated with alexithymia; moreover, somatic symptoms and alexithymia in adolescent patients with depressive disorders are correlated with GMV changes in different brain regions.
患有抑郁症的青少年患者通常会出现躯体症状，这对他们的治疗和预后有显著的负面影响。尽管如此，这些症状的特定脑成像特征研究较少。
采用汉密尔顿抑郁量表（HAMD-17）、儿童功能性躯体化量表（CSI）和多伦多述情障碍量表（TAS）来评估青少年抑郁症的临床症状。我们分析了患有抑郁症和躯体症状的青少年患者脑灰质体积（GMV）与临床症状之间的相关性。
有和没有功能性躯体症状（FSS）的抑郁症亚组在HAMD-17、CSI和TAS上的得分均高于正常对照组。有FSS的组在HAMD-17、CSI和TAS上的得分高于没有FSS的抑郁症组（<0.05）。CSI和TAS得分呈正相关（=0.378，<0.05）。有和没有FSS的抑郁症组右侧辅助运动区的GMV均高于正常对照组，且没有FSS的组的GMV高于有FSS的组（=29.394，<0.05）。在有FSS的抑郁症组中，右侧辅助运动区的GMV与CSI呈负相关（= -0.376，<0.05）。在表现出FSS的抑郁症组中，CSI得分与枕中回的GMV呈正相关（=0.665，=0.0001），TAS得分与尾状核的GMV呈正相关（=0.551，=0.001）。
青少年抑郁症的躯体症状与述情障碍有关；此外，患有抑郁症的青少年患者的躯体症状和述情障碍与不同脑区的GMV变化相关。
