Diprima Damiano, Gemoets Hannes, Bonciolini Stefano, Van Aken Koen
Ecosynth, Industrielaan 12, 9800 Deinze, Belgium.
Flow Chemistry Group, Van 't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Beilstein J Org Chem. 2023 Jul 31;19:1146-1154. doi: 10.3762/bjoc.19.82. eCollection 2023.
Sustainable oxidation protocols aim to provide an environmentally friendly and cost-effective method for the production of various chemicals and materials. The development of such protocols can lead to reduced energy consumption, fewer harmful byproducts, and increased efficiency in industrial processes. As such, this field of research is of great importance and interest to both academia and industry. This work showcases a sustainable and catalyst-free oxidation method for heteroatoms (e.g., S, P, and Se) using only air, water and light. An additional reaction pathway is proposed in which the incorporated oxygen on the heteroatoms originates from water. Furthermore, the addition of certain additives enhances productivity by affecting kinetics. The industrial potential is demonstrated by conveniently transferring the batch protocol to continuous flow using the HANU flow reactor, indicating scalability and improving safety.
可持续氧化方案旨在提供一种环境友好且具有成本效益的方法来生产各种化学品和材料。此类方案的开发可降低能源消耗、减少有害副产物，并提高工业生产过程的效率。因此，这一研究领域对学术界和工业界都极为重要且备受关注。这项工作展示了一种仅使用空气、水和光的用于杂原子（如硫、磷和硒）的可持续且无催化剂的氧化方法。提出了一种额外的反应途径，其中杂原子上结合的氧源自水。此外，添加某些添加剂可通过影响动力学来提高生产率。通过使用HANU流动反应器将间歇式方案方便地转换为连续流动，证明了其工业潜力，表明该方法具有可扩展性并提高了安全性。
