Ghosh Bhavna, Bose Anindya, Parmanik Ankita, Ch Sanjay, Paul Milan, Biswas Swati, Rath Goutam, Bhattacharya Debapriya
School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India.
Sri Jayadev College of Pharmaceutical Sciences, Naharkanta, Via: Balianta, Bhubaneswar, Odisha, 752101, India.
Heliyon. 2023 Jul 28;9(8):e18788. doi: 10.1016/j.heliyon.2023.e18788. eCollection 2023 Aug.
Antimicrobial resistance (AMR) is one of the most serious threats to today's healthcare system. The prime factor behind increasing AMR is the formation of complex bacterial biofilms which acts as the protective shield between the bacterial cell and the antimicrobial drugs. Among various nanoformulations, green synthesized metallic silver nanoparticles are currently gaining research focus in safely breaking bacterial biofilms due to the inherent antimicrobial property of silver. In the current work, the aqueous extract of the ayurvedic formulation Nishamalaki churna is used to exhibit one pot green synthesis of silver nanoparticles. The physicochemical characteristics of Nishamalaki churna extract mediated AgNPs were evaluated using various analytical techniques, like UV-Visible spectrophotometer, FT-IR spectroscopy, SEM, XRD, DLS-Zeta potential analyzer etc. The synthesized spherical AgNPs were well formed within the size range of 30 nm to 80 nm. Furthermore, the synthesized AgNPs showed potent antibacterial effects against two primary AMR-causing bacterial species like and with the successful destruction of their biofilm formation. Additionally, these AgNPs have shown profound antioxidant and anti-inflammatory activities as desirable add-on effects required by a prospective antibacterial agent.
抗菌耐药性（AMR）是当今医疗系统面临的最严重威胁之一。AMR增加的主要因素是形成复杂的细菌生物膜，它充当细菌细胞与抗菌药物之间的保护屏障。在各种纳米制剂中，绿色合成的金属银纳米颗粒由于银固有的抗菌特性，目前在安全破坏细菌生物膜方面正获得研究关注。在当前工作中，阿育吠陀制剂尼沙玛拉基 churn（Nishamalaki churna）的水提取物用于展示银纳米颗粒的一锅法绿色合成。使用各种分析技术，如紫外可见分光光度计、傅里叶变换红外光谱仪、扫描电子显微镜、X射线衍射仪、动态光散射-ζ电位分析仪等，对尼沙玛拉基 churn提取物介导的银纳米颗粒的物理化学特性进行了评估。合成的球形银纳米颗粒形成良好，尺寸范围在30纳米至80纳米之间。此外，合成的银纳米颗粒对两种主要的引起AMR的细菌物种如[此处原文缺失具体细菌名称]和[此处原文缺失具体细菌名称]显示出强大的抗菌作用，并成功破坏了它们的生物膜形成。此外，这些银纳米颗粒还表现出显著的抗氧化和抗炎活性，这是一种前瞻性抗菌剂所需的理想附加效果。
