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INTRODUCTION

There is emerging interest in medicinal plants in the biomedical field, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on medicinal plants has shown that nanotechnology could offer new solutions in the quality control, delivery aspects, or in sustaining herbal biological activities. This work reports on the preparation and characterization of silver nanoparticle-mediated plant extract.

METHODS

Ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, energy dispersive X-ray spectroscopy, high-resolution scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction have been used to characterize the prepared silver nanoparticles. The synthetic stability was studied by varying concentrations and pH of reactants. Egg albumin denaturation and carrageenan-induced rat paw edema model were used to ascertain the anti-inflammation.

RESULTS

Ultraviolet-visible spectroscopy gave plasmon resonance ranging between 420 and 480 nm while Fourier transform infrared spectroscopy proved nano interface functionalized with organics. The powder X-ray diffraction pattern is in agreement with silver and silver chloride nanoparticles of crystallite size 33.7 nm and 44.2 nm for silver and silver chloride, respectively. Energy dispersive X-ray spectroscopy enables elemental characterization of the particles consisting of silver and silver chloride among main elements. Spherical silver grain of 58.81 nm average size has been depicted with high-resolution scanning electron microscopy and high-resolution transmission electron microscopy. Inhibitions of 99% and 60% were obtained in vitro and in vivo, respectively.

CONCLUSION

The albumin denaturation and carrageenan-induced rat hind paw edema model to assess the anti-inflammatory potential of generated nanoparticles suggests that the silver nanoparticles may act as reducing/inhibiting agents on the release of acute inflammatory mediators. Hence, this work clearly demonstrated that silver nanoparticles mediated- could be considered as a potential source for anti-inflammatory drugs.

INTRODUCTION

METHODS

RESULTS

CONCLUSION

简介

由于具有多种具有抗炎、抗菌、抗病毒或抗肿瘤潜力的化学物质，药用植物在生物医学领域引起了人们的兴趣。对药用植物的研究表明，纳米技术可以在质量控制、输送方面或维持草药生物活性方面提供新的解决方案。本工作报道了银纳米颗粒介导的植物提取物的制备和表征。

方法

采用紫外-可见分光光度法、傅里叶变换红外光谱法、粉末 X 射线衍射法、能谱法、高分辨率扫描电子显微镜法、高分辨率透射电子显微镜法和选区电子衍射法对制备的银纳米粒子进行了表征。通过改变反应物的浓度和 pH 值来研究合成的稳定性。卵清蛋白变性和角叉菜胶诱导大鼠足肿胀模型用于确定抗炎作用。

结果

紫外-可见光谱给出了 420nm 至 480nm 之间的等离子体共振，而傅里叶变换红外光谱证明纳米界面用有机物功能化。粉末 X 射线衍射图谱与银和氯化银纳米粒子的晶粒度分别为 33.7nm 和 44.2nm 一致。能谱法能够对由银和银氯化物等主要元素组成的颗粒进行元素表征。高分辨率扫描电子显微镜和高分辨率透射电子显微镜显示，银的平均粒径为 58.81nm。体外和体内分别获得了 99%和 60%的抑制率。