腺苷A2A受体基因多态性（ADORA2A）与最大等长收缩疼痛相关。
Adenosine A receptor gene polymorphisms (ADORA2A) are associated with maximal concentric contraction pain.
作者信息
O'Connor Patrick J, Loy Bryan D, Lindheimer Jacob B, Covert Sarah F
机构信息
Department of Kinesiology, University of Georgia, Athens, GA 30602, United States.
Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States.
出版信息
Meta Gene. 2018 Dec;18:53-57. doi: 10.1016/j.mgene.2018.07.013.
OBJECTIVES
To test associations of adenosine A receptor gene () polymorphisms with maximal concentric contraction pain, caffeine-induced perceptual changes, and responses to mild eccentric injury.
DESIGN
Targeted candidate gene association study.
METHODS
(rs5751876) was genotyped in 26 adults. Pain of a maximal elbow flexor contraction was assessed. Participants performed 18 eccentric actions of the elbow flexors. Arm volume was measured before and 24- and 48-h post-injury. At 24- and 48-h post-injury, caffeine or placebo capsules were given using a randomized cross-over design and effort and pain were assessed.
RESULTS
Maximal concentric contraction pain was higher for the CC compared to the CT/TT group (effect size d = 0.89) and lower for the TT compared to the CT/CC group (d = 0.62). There were moderate sized differences between CC and TT/CT groups for post-injury exertion and arm volume 24-h post injury.
CONCLUSIONS
polymorphisms are moderately associated with muscle pain during maximal contractions in uninjured muscle.
目的
检测腺苷A受体基因（）多态性与最大等长收缩疼痛、咖啡因诱导的感知变化以及对轻度离心性损伤反应之间的关联。
设计
靶向候选基因关联研究。
方法
对26名成年人进行(rs5751876)基因分型。评估最大屈肘收缩时的疼痛。参与者进行18次屈肘肌的离心动作。在受伤前以及受伤后24小时和48小时测量手臂体积。在受伤后24小时和48小时，采用随机交叉设计给予咖啡因或安慰剂胶囊，并评估用力程度和疼痛程度。
结果
与CT/TT组相比，CC组的最大等长收缩疼痛更高（效应量d = 0.89）；与CT/CC组相比，TT组的疼痛更低（d = 0.62）。在受伤后24小时，CC组与TT/CT组在受伤后用力程度和手臂体积方面存在中等大小的差异。
结论
多态性与未受伤肌肉最大收缩时的肌肉疼痛中度相关。
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