School of Public Health, Wuhan University, 430071, China.
Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology & Business University, Beijing 100048, China.
Food Chem. 2024 Jan 1;430:137110. doi: 10.1016/j.foodchem.2023.137110. Epub 2023 Aug 6.
The main purpose of this study was to prepare zein-chondroitin sulfate (ZC) nanocomplex by anti-solvent co-precipitation, and to encapsulate, protect and controlled-release curcumin. As the proportion of chondroitin sulfate (CS) increased, the particle size, turbidity and zeta-potential of the ZC nanocomplexes all increased. When the mass ratio of zein and CS was 10:3, the ZC nanocomplex had small particle size (129 nm) and low polydispersity index (0.3). According to FTIR, FS, CD and XRD results, zein and CS were tightly bound by electrostatic attraction, hydrophobic effect and hydrogen bonding. The ZC nanocomplex was designed to encapsulate curcumin with high encapsulation efficiency (94.7%) and loading capacity (3.8%), and also enhanced the resistance of curcumin to light and thermal degradation by 2.9 and 2.4 times. It also exhibited controlled release capability during simulated gastrointestinal digestion. These results suggested the ZC nanocomplex is a good delivery vehicle to facilitate the application of curcumin.
本研究旨在通过反溶剂共沉淀法制备玉米醇溶蛋白-硫酸软骨素（ZC）纳米复合物，并对姜黄素进行包封、保护和控制释放。随着硫酸软骨素（CS）比例的增加，ZC 纳米复合物的粒径、浊度和 Zeta 电位均增加。当玉米醇溶蛋白和 CS 的质量比为 10:3 时，ZC 纳米复合物具有较小的粒径（129nm）和较低的多分散指数（0.3）。根据 FTIR、FS、CD 和 XRD 结果，玉米醇溶蛋白和 CS 通过静电吸引、疏水作用和氢键紧密结合。ZC 纳米复合物设计用于包封姜黄素，具有高包封效率（94.7%）和载药量（3.8%），并通过将姜黄素对光和热降解的抵抗力提高 2.9 和 2.4 倍。它还在模拟胃肠道消化过程中表现出控制释放能力。这些结果表明，ZC 纳米复合物是一种很好的递送载体，有利于姜黄素的应用。
