家畜疾病抗性的分子育种。

Molecular breeding of livestock for disease resistance.

机构信息

State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China; Sanya Institute of China Agricultural University, Sanya, 572025, China.

State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China; College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

出版信息

Virology. 2023 Oct;587:109862. doi: 10.1016/j.virol.2023.109862. Epub 2023 Aug 4.

DOI:10.1016/j.virol.2023.109862

PMID:37562287

Abstract

Animal infectious diseases pose a significant threat to the global agriculture and biomedicine industries, leading to significant economic losses and public health risks. The emergence and spread of viral infections such as African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and avian influenza virus (AIV) have highlighted the need for innovative approaches to develop resilient and disease-resistant animal populations. Gene editing technologies, such as CRISPR/Cas9, offer a promising avenue for generating animals with enhanced disease resistance. This review summarizes recent advances in molecular breeding strategies for generating disease-resistant animals, focusing on the development of disease-resistant livestock. We also highlight the potential applications of genome-wide CRISPR/Cas9 library screening and base editors in producing precise gene modified livestock for disease resistance in the future. Overall, gene editing technologies have the potential to revolutionize animal breeding and improve animal health and welfare.

摘要

动物传染病对全球农业和生物医学产业构成重大威胁，导致重大经济损失和公共卫生风险。非洲猪瘟病毒（ASFV）、猪繁殖与呼吸综合征病毒（PRRSV）、猪流行性腹泻病毒（PEDV）和禽流感病毒（AIV）等病毒感染的出现和传播突显了需要创新方法来培育具有弹性和抗疾病的动物种群。基因编辑技术，如 CRISPR/Cas9，为培育具有增强抗病能力的动物提供了有前途的途径。本综述总结了用于培育抗病动物的分子育种策略的最新进展，重点介绍了抗病家畜的开发。我们还强调了全基因组 CRISPR/Cas9 文库筛选和碱基编辑器在未来生产精确基因修饰家畜以提高抗病性方面的潜在应用。总的来说，基因编辑技术有可能彻底改变动物育种，改善动物健康和福利。