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粘蛋白结合黏附素:打开共生之门的关键。

Mucin-binding adhesins: A key to unlocking the door of mutualism.

机构信息

Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

出版信息

Cell Host Microbe. 2023 Aug 9;31(8):1254-1256. doi: 10.1016/j.chom.2023.07.007.

DOI:10.1016/j.chom.2023.07.007
PMID:37562359
Abstract

From corals to mammals, mucus is a conserved feature that prevents microbes from accessing the surfaces that produce it. However, interactions between mucus and microbes remain poorly understood. In this issue of Cell Host & Microbe, Smith et al. unveil that mucus binding by bacteria is crucial for host-microbe symbiosis.

摘要

从珊瑚到哺乳动物,黏液是一种保守的特征,可防止微生物接触到产生它的表面。然而,黏液和微生物之间的相互作用仍知之甚少。在本期《Cell Host & Microbe》中,Smith 等人揭示了细菌与黏液的结合对于宿主-微生物共生至关重要。

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Mucin-binding adhesins: A key to unlocking the door of mutualism.粘蛋白结合黏附素:打开共生之门的关键。
Cell Host Microbe. 2023 Aug 9;31(8):1254-1256. doi: 10.1016/j.chom.2023.07.007.
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Microbial adhesins to gastrointestinal mucus.微生物黏附素与胃肠道黏液。
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Structural insights into bacterial recognition of intestinal mucins.细菌识别肠道粘蛋白的结构见解
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The barrier and beyond: Roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis.障碍与超越:肠道黏液和黏蛋白型 O-糖基化在指导宿主-微生物共生的抵抗和耐受防御策略中的作用。
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Mucus and Mucins: The Underappreciated Host Defence System.黏液和黏蛋白:被低估的宿主防御系统。
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Environ Microbiol Rep. 2025 Oct;17(5):e70176. doi: 10.1111/1758-2229.70176.
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Mucosomes as next-generation drug carriers for treating mucus-resident bacterial infections and biofilms.黏液小体作为用于治疗驻留于黏液中的细菌感染和生物膜的下一代药物载体。
Sci Rep. 2025 Jul 25;15(1):27071. doi: 10.1038/s41598-025-10496-y.
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Understanding the probiotic health benefits of subsp. , BB-12™.
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