Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
Trends Microbiol. 2012 Jan;20(1):30-9. doi: 10.1016/j.tim.2011.10.001. Epub 2011 Nov 14.
The gastrointestinal tract (GIT) is lined by a layer of mucus formed by mucin glycoproteins. This layer constitutes a physical and chemical barrier between the intestinal contents and the underlying epithelia. In addition to this protective role, mucins harbor glycan-rich domains that provide preferential binding sites for pathogens and commensal bacteria. Although mucus-microbial interactions in the GIT play a crucial role in determining the outcome of relationships of both commensal and pathogens with the host, the adhesins and ligands involved in the interaction are poorly delineated. This review focuses on the current knowledge of microbial adhesins to gastrointestinal mucus and mucus components.
胃肠道（GIT）由一层由粘蛋白糖蛋白组成的粘液所覆盖。这层粘液构成了肠内容物和底层上皮之间的物理和化学屏障。除了这种保护作用外，粘蛋白还具有富含聚糖的结构域，为病原体和共生菌提供了优先结合位点。尽管胃肠道中粘液-微生物的相互作用在决定共生菌和病原体与宿主关系的结果方面起着至关重要的作用，但参与相互作用的黏附素和配体还没有得到很好的描述。这篇综述重点介绍了微生物对胃肠道粘液和粘液成分的黏附素的最新认识。
