Sten-Knudsen O, Ussing H H
J Membr Biol. 1981;63(3):233-42. doi: 10.1007/BF01870984.
The time dependent (i.e., nonstationary) unidirectional fluxes through a multilayered system consisting of sandwiched layers of arbitrary composition and exhibiting arbitrary potential and resistance profiles have been calculated, assuming that the flux is governed by the Smoluchowski equation (i.e., a flux resulting from a diffusion process superimposed upon a migration and/or a convection process, where part of the latter may arise from an active transport process). It is shown that during the building up of the concentration profile of the isotope inside the system towards the stationary value the ratio between the two oppositely directed, time-dependent unidirectional fluxes is, from the very first appearance of the isotope in the surrounding solutions, equal to the value of the stationary flux ratio. The practical implications of this result are discussed.
通过由任意组成的夹心层构成且具有任意电势和电阻分布的多层系统的时间相关(即非平稳)单向通量已被计算出来,假设通量由斯莫卢霍夫斯基方程支配(即由叠加在迁移和/或对流过程上的扩散过程产生的通量,其中后者的一部分可能源于主动运输过程)。结果表明,在系统内部同位素的浓度分布向稳态值建立的过程中,从同位素在周围溶液中首次出现起,两个相反方向的、时间相关的单向通量之比就等于稳态通量比的值。讨论了该结果的实际意义。