Chumasov E I, Svetikova K M, Gusikhina V I
Biull Eksp Biol Med. 1986 Sep;102(9):374-7.
An experimental model of a seamless end-to-end joining of severed sciatic nerve (with gaps between the two ends 5-8 mm-wide) using an implanted arterial vessel was elaborated on random bred and inbred Wistar rats. Histological examination showed that nerve regeneration along the implanted arterial lumen was directly oriented and was not accompanied by neuroma formation which was always the case in the control. It took some nerve fibers 20 days to join the gap between the cut nerve ends. In 4 months myelination of regenerating fibers was observed in the blood vessel lumen, in 3 months the lumen was filled with bundles of myelinated fibers, and in 9 months the structure of the regenerating nerve was similar to that of the mature trunk observed in animals. The elaborated experimental model is to be employed in the studies of reparatory histogenesis in peripheral nervous tissues. The data obtained may be used in neurosurgery.
在随机繁殖和近交的Wistar大鼠上建立了一种使用植入动脉血管对切断的坐骨神经进行无缝端对端连接（两端之间间隙为5 - 8毫米宽）的实验模型。组织学检查表明，沿植入动脉管腔的神经再生是直接定向的，且未伴有神经瘤形成，而在对照组中总是会形成神经瘤。一些神经纤维需要20天才能连接切断的神经末端之间的间隙。4个月时在血管管腔内观察到再生纤维的髓鞘形成，3个月时管腔内充满了成束的有髓纤维，9个月时再生神经的结构与动物体内观察到的成熟神经干相似。所建立的实验模型将用于外周神经组织修复组织发生的研究。所获得的数据可用于神经外科手术。
