子宫内膜癌中淋巴管间隙侵犯（LVSI）与组织学肿瘤分级及肌层浸润的相关性：一项综述研究
Association of Lymphovascular Space Invasion (LVSI) with Histological Tumor Grade and Myometrial Invasion in Endometrial Carcinoma: A Review Study.
作者信息
Rafiee Azita, Mohammadizadeh Fereshteh
机构信息
Pathologist, Iranian Medical and Pathology Laboratory, Zahedan, Iran.
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2023 Jun 28;12:159. doi: 10.4103/abr.abr_52_23. eCollection 2023.
Abstract
Endometrial carcinoma is one of the most frequent gynecological cancers in developed countries. Lymphovascular space invasion (LVSI), histological grade, and myometrial invasion (MMI) are important prognostic factors of endometrial carcinoma. LVSI is considered an independent poor prognostic factor in endometrial carcinoma. Based on the importance of LVSI, this study aimed to discuss the association of LVSI with tumor grade and MMI. A search of PubMed, EMBASE, Web of Science, Scopus, Google Scholar, and Cochrane Library was carried out to collect related studies. Consequently, most studies showed that LVSI is significantly associated with higher histologic grade and deep MMI.
摘要
子宫内膜癌是发达国家最常见的妇科癌症之一。淋巴管间隙浸润（LVSI）、组织学分级和肌层浸润（MMI）是子宫内膜癌重要的预后因素。LVSI被认为是子宫内膜癌独立的不良预后因素。基于LVSI的重要性，本研究旨在探讨LVSI与肿瘤分级和MMI之间的关联。通过检索PubMed、EMBASE、Web of Science、Scopus、谷歌学术和Cochrane图书馆来收集相关研究。结果，大多数研究表明LVSI与更高的组织学分级和深部MMI显著相关。
相似文献
1
Association of Lymphovascular Space Invasion (LVSI) with Histological Tumor Grade and Myometrial Invasion in Endometrial Carcinoma: A Review Study.子宫内膜癌中淋巴管间隙侵犯（LVSI）与组织学肿瘤分级及肌层浸润的相关性：一项综述研究
Adv Biomed Res. 2023 Jun 28;12:159. doi: 10.4103/abr.abr_52_23. eCollection 2023.
2
The grading of lymphovascular space invasion in endometrial carcinoma.子宫内膜癌中淋巴管间隙浸润的分级
Cancer. 1999 Nov 15;86(10):2090-7.
3
Lymphovascular space invasion in endometrial carcinoma: Tumor size and location matter.子宫内膜癌中的淋巴管间隙浸润：肿瘤大小和位置至关重要。
Surg Oncol. 2021 Jun;37:101541. doi: 10.1016/j.suronc.2021.101541. Epub 2021 Mar 6.
4
The diagnostic performance of ADC value for tumor grade, deep myometrial invasion and lymphovascular space invasion in endometrial cancer: a meta-analysis.表观扩散系数（ADC）值对子宫内膜癌肿瘤分级、肌层深部浸润及淋巴管间隙浸润的诊断效能：一项Meta分析
Acta Radiol. 2019 May 1:284185119841988. doi: 10.1177/0284185119841988.
5
Prediction of lymphovascular space invasion in patients with endometrial cancer.预测子宫内膜癌患者的淋巴管血管侵犯。
Int J Med Sci. 2021 Jun 1;18(13):2828-2834. doi: 10.7150/ijms.60718. eCollection 2021.
6
Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients.子宫肌层浸润与子宫内膜癌的淋巴管间隙浸润、淋巴结转移、复发及总生存的相关性：一项纳入79项研究共68870例患者的Meta分析
Front Oncol. 2021 Oct 21;11:762329. doi: 10.3389/fonc.2021.762329. eCollection 2021.
7
Association of Tumor Size With Myometrial Invasion, Lymphovascular Space Invasion, Lymph Node Metastasis, and Recurrence in Endometrial Cancer: A Meta-Analysis of 40 Studies With 53,276 Patients.肿瘤大小与子宫内膜癌肌层浸润、淋巴管间隙浸润、淋巴结转移及复发的相关性：一项纳入40项研究共53276例患者的Meta分析
Front Oncol. 2022 Jun 2;12:881850. doi: 10.3389/fonc.2022.881850. eCollection 2022.
8
Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer.早期子宫内膜癌患者肿瘤直径与淋巴管血管间隙浸润的关系。
Int J Gynaecol Obstet. 2013 Nov;123(2):142-5. doi: 10.1016/j.ijgo.2013.05.012. Epub 2013 Jul 31.
9
Risk Factors for Lymph Node Metastasis among Lymphovascular Space Invasion-Positive Women with Endometrioid Endometrial Cancer Clinically Confined to the Uterus.脉管侵犯阳性且局限于子宫的子宫内膜样型子宫内膜癌患者发生淋巴结转移的风险因素。
Oncol Res Treat. 2018;41(12):750-754. doi: 10.1159/000492585. Epub 2018 Nov 13.
10
Is Substantial Lymphovascular Space Invasion Prognostic for Clinical Outcomes in Type II Endometrial Cancer?是否存在实质性淋巴管血管侵犯对 II 型子宫内膜癌的临床结局具有预后意义？
Clin Oncol (R Coll Radiol). 2022 Jul;34(7):452-458. doi: 10.1016/j.clon.2022.02.018. Epub 2022 Mar 6.
引用本文的文献
1
A Nomogram for Preoperative Prediction of Tumor Aggressiveness and Lymphovascular Space Involvement in Patients with Endometrial Cancer.子宫内膜癌患者术前预测肿瘤侵袭性和淋巴管间隙受累的列线图
J Clin Med. 2025 Jun 2;14(11):3914. doi: 10.3390/jcm14113914.
2
Onvansertib exhibits anti-proliferative and anti-invasive effects in endometrial cancer.奥万塞替布对子宫内膜癌具有抗增殖和抗侵袭作用。
Front Pharmacol. 2025 Mar 17;16:1545038. doi: 10.3389/fphar.2025.1545038. eCollection 2025.
3
Development of a Nomogram-Based Online Calculator for Predicting Cancer-Specific Survival in Patients With Digestive Tract Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNENs): An Analysis of the SEER Database.基于列线图的在线计算器的开发，用于预测消化道混合性神经内分泌-非神经内分泌肿瘤（MiNENs）患者的癌症特异性生存率：监测、流行病学和最终结果（SEER）数据库分析
Cancer Rep (Hoboken). 2025 Feb;8(2):e70156. doi: 10.1002/cnr2.70156.
4
Integrating proteomics and explainable artificial intelligence: a comprehensive analysis of protein biomarkers for endometrial cancer diagnosis and prognosis.整合蛋白质组学与可解释人工智能：子宫内膜癌诊断和预后蛋白质生物标志物的综合分析
Front Mol Biosci. 2024 Jun 3;11:1389325. doi: 10.3389/fmolb.2024.1389325. eCollection 2024.
5
Atlas of Tumor and Tumor Microenvironment Cells of Lymphovascular Space Invasion (LVSI) in High-Grade Serous Endometrial Adenocarcinoma: A Case Study.高级别浆液性子宫内膜腺癌淋巴管血管间隙侵犯（LVSI）肿瘤及肿瘤微环境细胞图谱：病例研究。
Int J Mol Sci. 2024 Mar 19;25(6):3441. doi: 10.3390/ijms25063441.
本文引用的文献
1
Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients.子宫肌层浸润与子宫内膜癌的淋巴管间隙浸润、淋巴结转移、复发及总生存的相关性：一项纳入79项研究共68870例患者的Meta分析
Front Oncol. 2021 Oct 21;11:762329. doi: 10.3389/fonc.2021.762329. eCollection 2021.
2
Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer.定义子宫内膜癌中的显著淋巴管间隙浸润
Int J Gynecol Pathol. 2022 May 1;41(3):220-226. doi: 10.1097/PGP.0000000000000806. Epub 2021 Jul 13.
3
Prediction of lymphovascular space invasion in patients with endometrial cancer.预测子宫内膜癌患者的淋巴管血管侵犯。
Int J Med Sci. 2021 Jun 1;18(13):2828-2834. doi: 10.7150/ijms.60718. eCollection 2021.
4
New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines.基于更新后的ESGO/ESTRO/ESP指南看子宫内膜癌的新病理及临床见解
Cancers (Basel). 2021 May 26;13(11):2623. doi: 10.3390/cancers13112623.
5
Lymphovascular space invasion in endometrial carcinoma: Tumor size and location matter.子宫内膜癌中的淋巴管间隙浸润：肿瘤大小和位置至关重要。
Surg Oncol. 2021 Jun;37:101541. doi: 10.1016/j.suronc.2021.101541. Epub 2021 Mar 6.
6
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
7
Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer.大量淋巴血管空间浸润（LVSI）可预测低危早期子宫内膜癌的远处复发和不良预后。
J Gynecol Oncol. 2021 Mar;32(2):e11. doi: 10.3802/jgo.2021.32.e11. Epub 2021 Jan 11.
8
Impact of uterine manipulator on oncological outcome in endometrial cancer surgery.子宫操作器对子宫内膜癌手术中肿瘤学结果的影响。
Am J Obstet Gynecol. 2021 Jan;224(1):65.e1-65.e11. doi: 10.1016/j.ajog.2020.07.025. Epub 2020 Jul 18.
9
Is Tumor-Free Distance an Independent Prognostic Factor for Early-Stage Endometrioid Endometrial Cancer?无瘤切缘距离是早期子宫内膜样腺癌的独立预后因素吗？
J Oncol. 2020 Apr 14;2020:2934291. doi: 10.1155/2020/2934291. eCollection 2020.
10
Novel preoperative predictive score to evaluate lymphovascular space involvement in endometrial cancer: an aid to the sentinel lymph node algorithm.新型术前预测评分评估子宫内膜癌淋巴管血管侵犯：有助于前哨淋巴结算法。
Int J Gynecol Cancer. 2020 Jun;30(6):806-812. doi: 10.1136/ijgc-2019-001016. Epub 2020 Apr 12.
Zotero 插件